EX7L_RHOBA
ID EX7L_RHOBA Reviewed; 442 AA.
AC Q7UTZ9;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RB3598;
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX294139; CAD73285.1; -; Genomic_DNA.
DR RefSeq; NP_865601.1; NC_005027.1.
DR RefSeq; WP_011119437.1; NC_005027.1.
DR AlphaFoldDB; Q7UTZ9; -.
DR SMR; Q7UTZ9; -.
DR STRING; 243090.RB3598; -.
DR EnsemblBacteria; CAD73285; CAD73285; RB3598.
DR KEGG; rba:RB3598; -.
DR PATRIC; fig|243090.15.peg.1668; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_0; -.
DR InParanoid; Q7UTZ9; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 2.
DR Pfam; PF02601; Exonuc_VII_L; 2.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..442
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000226306"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 48313 MW; 383E87087AB13EFC CRC64;
MSDSTQFSLF DSGDDEPAKV TAPKRKVARK KRSSSSSDDA ISISELTRQI KSTVESGFPG
VWVAGEITDI ARPRSGHLYF TLKDERSQIR GVMWRSVAER LPFELDDGQS VLCMGDVEVY
AARGSYQLVV RKCQPQGMGA LQLAFAQLQA KLQAEGLFEP ERKRLLPRVP RRVAIVTSPT
GAAIQDFLQA AAQRHAGIEI VLIPASVQGP GSVESLIDGM RAAHRMRPQP DVLIVSRGGG
SLEDLWSFND EQLVRAIAAS RIPTVSAVGH EIDVTLADLV ADVRALTPTD AASRVLPDRD
SMVAALDALG QMMATNLFRR VHSERQRLEN WESRPVFQNP FEMVHDRSRE VDDWDERGRS
AIWRRLEQAQ AKLATVAAAQ SALSPLAVLA RGYSVTQTDA GKVVRSTGDV QPGDSLRTRL
TDGDVISVVS RHESKPGNSD SA
