EX7L_RHOCS
ID EX7L_RHOCS Reviewed; 523 AA.
AC B6IXD4;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RC1_3609;
OS Rhodospirillum centenum (strain ATCC 51521 / SW).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Rhodospirillum.
OX NCBI_TaxID=414684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51521 / SW;
RA Touchman J.W., Bauer C., Blankenship R.E.;
RT "Genome sequence of Rhodospirillum centenum.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000613; ACJ00958.1; -; Genomic_DNA.
DR RefSeq; WP_012568734.1; NC_011420.2.
DR AlphaFoldDB; B6IXD4; -.
DR STRING; 414684.RC1_3609; -.
DR EnsemblBacteria; ACJ00958; ACJ00958; RC1_3609.
DR KEGG; rce:RC1_3609; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_5; -.
DR OMA; LVWPVKV; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000001591; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..523
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000205681"
FT REGION 502..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 56353 MW; E1A7FBC0DB7AA36E CRC64;
MSYDPADLPP RTGSNLPEMS VGDLARALKR TVEDAYGYVR VRGEISQPKR HSSGHVYLRL
KDETAVLEAV CWKGVAARLS VRPEEGMEVV CTGRLTTYPG RSQYQLVIET MELAGEGALL
KMLEERKRRL AAEGLFAPER KKPLPFLPEV IGVVTSPTGA VIRDILHRLA DRFPRHVLLW
PVAVQGEGAA DQVARAIAGF NAIAPGGPVP RPDLIIVARG GGSLEDLMPF NEEAVVRAAA
ASAIPLISAV GHETDTTLID FASDRRAPTP TAAAEMAVPV RTELLAQVLD DGRRLHQCLS
RAIDTRRSHV EGLGRGLGDP RALLEGCIQR LDDRAERLEL SLRTGLERRH AAVQQLGIRL
RHPREVIGLA AARADAAGRA LRAGFDRAVT VEQGRFHRVA DRLSPLPLRR QIDAGRDRLD
ALPPRLAQAH ARRLDQAGQR LVALGQLLES YSYKGVLERG FVLVADAEGR PVTRAADTAP
GQPVALRFAD GTVGAVVDGA APGASPAART RAGKAKADQG SLF
