EX7L_RICAE
ID EX7L_RICAE Reviewed; 444 AA.
AC C3PPC7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RAF_ORF0932;
OS Rickettsia africae (strain ESF-5).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=347255;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ESF-5;
RX PubMed=19379498; DOI=10.1186/1471-2164-10-166;
RA Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B.,
RA Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.;
RT "Analysis of the Rickettsia africae genome reveals that virulence
RT acquisition in Rickettsia species may be explained by genome reduction.";
RL BMC Genomics 10:166-166(2009).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP001612; ACP53787.1; -; Genomic_DNA.
DR RefSeq; WP_012719934.1; NC_012633.1.
DR AlphaFoldDB; C3PPC7; -.
DR SMR; C3PPC7; -.
DR PRIDE; C3PPC7; -.
DR EnsemblBacteria; ACP53787; ACP53787; RAF_ORF0932.
DR KEGG; raf:RAF_ORF0932; -.
DR HOGENOM; CLU_023625_2_0_5; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000002305; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..444
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000205682"
SQ SEQUENCE 444 AA; 49957 MW; D43BB934C161AC9A CRC64;
MLDNFIAHQT TKEFSVSEIS NKIKELLENN FGYIKVKGEI SGLKIANSGH AYFNLKENTA
ILACTCWRPI LAKIKFPLND GMEVVISGKL SSYAGNSRYQ LSVDNLQPTG LGAMLQILNE
RKARLEKEGL FNKIRIPIPF LPDKIGVITS ITGAVIKDII HRIRERFPTR IIIWPVSVQG
ENSGNEIAEA IEGFNNLEEV NKPRVIIVAR GGGSIEDLWS FNDEILVRAA YNSKIPIISA
VGHEVDYTLI DLAADKRAPT PTAAAEFAVP VHSILNNTLQ SYEKILLNNT SRLIKYHEQN
IVNYNKIHRY LSHYINHRQQ LLDETGFNLL DALPCFIELQ ETKIKSFSKE RVNPAKIINY
KTLELTHQTA YLSKSANNTL KNFEYKLELN STLLASLDYH NVLKRGFAIV KGETGNFLSS
KITAANEKIF NIKFSDGEIK VVRA
