ID   EX7L_RICCK              Reviewed;         444 AA.
AC   A8EZN6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=A1E_04470;
OS   Rickettsia canadensis (strain McKiel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=293613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=McKiel;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia canadensis.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000409; ABV73819.1; -; Genomic_DNA.
DR   RefSeq; WP_012149014.1; NC_009879.1.
DR   AlphaFoldDB; A8EZN6; -.
DR   SMR; A8EZN6; -.
DR   STRING; 293613.A1E_04470; -.
DR   EnsemblBacteria; ABV73819; ABV73819; A1E_04470.
DR   KEGG; rcm:A1E_04470; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_2_0_5; -.
DR   OMA; WPAVRFE; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000007056; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..444
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000048782"
SQ   SEQUENCE   444 AA;  49909 MW;  7456F147FA8A84E4 CRC64;
     MLDNFIVNQA TKEFSVSEIS NKIKELLENN FGYIKIKGEI SGFKIASSGH AYFNLKENTA
     ILACTCWRPT LAKIKFPLKD GMEVVISGKL SSYAGNSRYQ LAVDNLQPAG LGTMLQILNE
     RKTRLEKEGL FNKRRIPIPF LPTRIGVITS ITGAVIKDII HRIRERFPTH IIIWPVSVQG
     ENSGNEIAAA IEGFNKLEEA NKPSVIIVAR GGGSIEDLWS FNDEILVRAA YNSKIPIISA
     VGHEVDYTLI DLAADKRAPT PTAAAEFAVP VRSILNNTLQ SYEKVLLNNT KQLINYHEQN
     IANYDKIHRY LTNYINHRQQ LLDETGFNLL DVLPCFIELQ ETKLKFCSKE RINPAKIINY
     KTLELTHQTA YLSKSANNTL KNFEYKLELN STLLASLDYH NVLKRGFAIV KGAMGNFLSS
     KITAADEKIF NIKFSDGEIK VVRN