EX7L_RICFE
ID EX7L_RICFE Reviewed; 450 AA.
AC Q4UMV4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RF_0253;
OS Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=315456;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1525 / URRWXCal2;
RX PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA Parinello H., Claverie J.-M., Raoult D.;
RT "The genome sequence of Rickettsia felis identifies the first putative
RT conjugative plasmid in an obligate intracellular parasite.";
RL PLoS Biol. 3:1-12(2005).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY61104.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000053; AAY61104.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_039594855.1; NC_007109.1.
DR AlphaFoldDB; Q4UMV4; -.
DR SMR; Q4UMV4; -.
DR STRING; 315456.RF_0253; -.
DR EnsemblBacteria; AAY61104; AAY61104; RF_0253.
DR KEGG; rfe:RF_0253; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_2_0_5; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000008548; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..450
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000273122"
SQ SEQUENCE 450 AA; 50400 MW; 265852FBC2464AAC CRC64;
MLDNFIANQA TKEFSVSEIS NKIKELLENN FGYIKVKGEI SGLKIASSGH AYFNLKENTA
ILACTCWRPI LAKIKFPLND GMEVVISGKL SSYAGNSRYQ LSVDNLQPAG LGAMLQILNE
RKARLEKEGL FNKIRIPIPF LPDKIGVITS ITGAVIKDII HRIRERFPTR IIIWPVSVQG
ENSGNEIAEA IEGFNNLEEI NKPSVIIVAR GGGSIEDLWS FNDEILVRAA YNSKIPIISA
VGHEVDYTLI DLAADKRAPT PTAAAEFAVP VRSILNNTLQ SYEKILLNNT SRLIKYHEQN
IINYDKIHRY LSHYMNNKQQ LLDETGFNLL DALPCFIELQ ETKIKSFSKE RVNPAKILNY
KTLELTHQTA YLSKSANNTL KNFEYKLELN STLLASLDYN NVLKRGFAIV KGETGNFLSS
KITAANEKIF NIKFSDGEIK VVRNTVIASD
