EX7L_RICPR
ID EX7L_RICPR Reviewed; 453 AA.
AC Q9ZCP8;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RP675;
OS Rickettsia prowazekii (strain Madrid E).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=272947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; AJ235272; CAA15112.1; -; Genomic_DNA.
DR PIR; F71673; F71673.
DR RefSeq; NP_221036.1; NC_000963.1.
DR RefSeq; WP_004596348.1; NC_000963.1.
DR AlphaFoldDB; Q9ZCP8; -.
DR SMR; Q9ZCP8; -.
DR STRING; 272947.RP675; -.
DR EnsemblBacteria; CAA15112; CAA15112; CAA15112.
DR GeneID; 57569801; -.
DR KEGG; rpr:RP675; -.
DR PATRIC; fig|272947.5.peg.696; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_2_0_5; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000002480; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..453
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000197873"
SQ SEQUENCE 453 AA; 51059 MW; 7C5FF24F79ACA290 CRC64;
MIDNCIANQA SKEFSVSEIS NKIKELLENN FGYIKVKGEI SGLKRASSGH AYFNLKENTA
ILACTCWRPI LAKIKFPLND GMEVVIGGKL SSYSGNSRYQ LSVDNLQPAG LGAMLQILNE
RKTRLEKEGL FNKKRIPIPF LPDKIGVITS ITGAVIKDII HRIRERFPTR IIIWQVSVQG
ENSGHEMAEA IEGFNNLEEI HKPSVIIVAR GGGSIEDLWS FNDEILVRAA YNSKIPIISA
VGHEADYTLI DLAADKRAPT PTAAAEFAVP VRSILNNTIQ SYEKILFNNT NRLIKYHEQS
IVNYDKIHSY FSYYINNRQQ LLDEIGFNLL DVLIRFIALK ETKIKSFSKE RINYAKIINY
KILELTHQTA YLFKSVNNTL KNFEYKLELN STLLASLDYH NVLKRGFAIV KGDAGNFLSS
KSAATNEQSL NIKFFDGEIN VVLSCHDLNT RSN
