ID   EX7L_SINMW              Reviewed;         526 AA.
AC   A6UF86;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Smed_3498;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000738; ABR62316.1; -; Genomic_DNA.
DR   RefSeq; WP_012067695.1; NC_009636.1.
DR   RefSeq; YP_001329151.1; NC_009636.1.
DR   AlphaFoldDB; A6UF86; -.
DR   SMR; A6UF86; -.
DR   STRING; 366394.Smed_3498; -.
DR   EnsemblBacteria; ABR62316; ABR62316; Smed_3498.
DR   GeneID; 61611051; -.
DR   KEGG; smd:Smed_3498; -.
DR   PATRIC; fig|366394.8.peg.6749; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..526
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000048786"
FT   REGION          499..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  56764 MW;  FB390C2B94BA2782 CRC64;
     MTSFFDSESP SNVAEYSVSE LSGSIKRTIE QTFEHVRVRG EISGYRGPHS SGHAYFTLKD
     DRARIDAVVW KGTFARLKFR PEEGMEVIAT GRVTTFPGSS KYQVVIDALE PAGAGALMAL
     IEERKRKLAA EGLFDAGRKR PLPFMPKVIG VVTSPTGAVI RDILHRIADR FPVHVLVWPV
     RVQGDGACEE IVAAIEGFNA LQPGGPIARP DVLIVARGGG SLEDLWCFND EAMVRAAAGS
     AIPLISAVGH ETDWTLIDHA ADQRAPTPTG AAEMAVPVKA DLEAQLASLS ARLKGAAVRQ
     MDNRRQTLRS LARALPSLDQ LLALPRRRFD EAAAGLGRGL QMNTANKRRS FERSAAHLRP
     DLLTARIVDR RQRVVDAVNR AERIVERQVH RGAARVASAD ASLRALPSRL IGQVHRASDR
     VSAMSRRADA AIAADLRRLK SAVAAQDRVL QSLSYRNVLQ RGFALVRDAA GEPVKQAAAV
     HSGMALSVEF ADGRVAAVAG EDGTPSQAPK KRPARAGEPT KQGSLF