ID   AGUA_LATSS              Reviewed;         365 AA.
AC   Q8RPX2; Q38ZK8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; Synonyms=labD;
GN   OrderedLocusNames=LCA_0070;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11832506; DOI=10.1099/00221287-148-2-421;
RA   Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C.,
RA   Alpert C.-A., Zagorec M.;
RT   "Physical and genetic map of the Lactobacillus sakei 23K chromosome.";
RL   Microbiology 148:421-431(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI54369.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF349639; AAL98713.1; -; Genomic_DNA.
DR   EMBL; CR936503; CAI54369.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011373784.1; NC_007576.1.
DR   AlphaFoldDB; Q8RPX2; -.
DR   SMR; Q8RPX2; -.
DR   STRING; 314315.LCA_0070; -.
DR   PRIDE; Q8RPX2; -.
DR   EnsemblBacteria; CAI54369; CAI54369; LCA_0070.
DR   KEGG; lsa:LCA_0070; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_1_0_9; -.
DR   OrthoDB; 771174at2; -.
DR   BioCyc; LSAK314315:LCA_RS00335-MON; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
DR   TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194327"
FT   ACT_SITE        356
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   365 AA;  41041 MW;  9A99197E2D992CDA CRC64;
     MKTLQTSPKK DGYRMPGEFE AHKDVYLLWP ERPDNWREGA KPAQATFAKV AETIAQFESV
     TVGVSDRQYT NARHMLADNI QVVEMSNNDS WIRDCGPTFV VNDKGDSRGV DWTFNAWGGL
     VDGLYFPWDK DDRVAQKVCE IEGRDRYRLD DLVLEGGSTH VDGEGTLLVT EECLLSDGRN
     PQLSKEQIES ILKEYLNVEK IIWLKKGIYL DETNGHVDNI ANFVKPGQVV LAWTDDQSDP
     QYAISKENYD MLINETDAKG RKLQVEKLYL PKPILITEAE SQGVDTVDGT LPRLAGDRLA
     ASYVNYYTAN GGIVFPLFND PMDEKAQEIL QKLYPDRKIV GVPAREILLG GGNIHCITQQ
     IPAGR