ID   EX7L_ZYMMO              Reviewed;         544 AA.
AC   Q9FDL4; Q5NQT0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=ZMO0300;
OS   Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Zymomonadaceae; Zymomonas.
OX   NCBI_TaxID=264203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RA   Lee H.J., Kang H.S.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA   Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA   Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA   Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AF212041; AAG02155.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV88924.1; -; Genomic_DNA.
DR   RefSeq; WP_011240235.1; NZ_CP035711.1.
DR   AlphaFoldDB; Q9FDL4; -.
DR   SMR; Q9FDL4; -.
DR   STRING; 264203.ZMO0300; -.
DR   EnsemblBacteria; AAV88924; AAV88924; ZMO0300.
DR   GeneID; 58026162; -.
DR   KEGG; zmo:ZMO0300; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; WPAVRFE; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000001173; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..544
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197908"
FT   REGION          522..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        59
FT                   /note="G -> R (in Ref. 1; AAG02155)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        448
FT                   /note="C -> Y (in Ref. 1; AAG02155)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   544 AA;  60593 MW;  3F55ADB77B4F7891 CRC64;
     MNSFSFDGSD LLAKSDATDN VRAFSVSEIS GALKRTVEDA FSHIRVRGEI SGFTQAGSGH
     CYLALKDDKA VLDSVIWRGV VSRISFRPEN GMEVIATGRL TTYAGRSRYQ LVIEQLEIAG
     QGALMALLDR RRRMLAEEGL FNADRKRALP FMPKIIGVVS SPSGAVIRDI LHRLADRCPT
     HVILWPVPVQ GDQAAAKVAA AVRGFSALKA GDAIPRPDLL IVARGGGSLE DLWPFNEEIL
     VRAVAESSIP VISAVGHETD TTLCDYAADL RAPTPTAAAE LAVPVRSELV NGLNNLHLRM
     NNAIARHAKL SEERLEAVRR RLPDGERLLA PFIQLFDDRA SQLERDISER MTHARHKLNF
     YAATLRPALL QARIAREQAR LSACRLPTGQ RLVIQEQQKL DNVTRRLKQA YQQRLSHADL
     RFKFLAEKLQ PLLLEQRWQQ KAELLAACSL KPELVTARLN IWQKNIDQLW RVAEQAHPDK
     ILAKGYARVE DSHSHVVSNA HDAKTHKRLN LIFHDGSVWV APETPPKSRK ADNPPEPPEQ
     TSFL