ID   AGUA_MYCMS              Reviewed;         364 AA.
AC   Q6MSR8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=MSC_0701;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR   EMBL; BX293980; CAE77320.1; -; Genomic_DNA.
DR   RefSeq; NP_975678.1; NC_005364.2.
DR   AlphaFoldDB; Q6MSR8; -.
DR   SMR; Q6MSR8; -.
DR   STRING; 272632.MSC_0701; -.
DR   EnsemblBacteria; CAE77320; CAE77320; MSC_0701.
DR   KEGG; mmy:MSC_0701; -.
DR   PATRIC; fig|272632.4.peg.754; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_1_0_14; -.
DR   OMA; WCRDHGP; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
DR   TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194335"
FT   ACT_SITE        355
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   364 AA;  41717 MW;  E825591584C36D96 CRC64;
     MSKKMNSTPK KDGFWMPGEW EKHDQCWMIW PERSDNWRLG AKPAQRVFVN VANAIAKYEK
     VTMLVSHQQF ENARNLLDQN VRVIEMSNDD SWMRDVGPTI VKNKDGEIRG VDWVFNAWEG
     FKGGLYFPWD KDDAIARKVC EICNIDYYRT DFVLEGGSIH TDGDGTLYTT EECLLNENRN
     PDLTKEQIEE NLKEYCGVEK VIWLPLGVYN DETNGHVDNL LNVVSPGHVV LTWTDDTTDP
     QYERSKLAYD ILTNTLDAKG RKIKVTKLHQ PGPLFITKEE AEGIDVCDTM SREPEQRMPA
     SYANYYIANN AIILPIFGDK YDDLAVKTLQ SVYPNHKIET VMAREILLGG GNIHCITQQQ
     PTTK