EX7S_GEOKA
ID EX7S_GEOKA Reviewed; 79 AA.
AC Q75TB9; Q5KXA7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Exodeoxyribonuclease 7 small subunit {ECO:0000255|HAMAP-Rule:MF_00337};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00337};
DE AltName: Full=Exodeoxyribonuclease VII small subunit {ECO:0000255|HAMAP-Rule:MF_00337};
DE Short=Exonuclease VII small subunit {ECO:0000255|HAMAP-Rule:MF_00337};
GN Name=xseB {ECO:0000255|HAMAP-Rule:MF_00337}; OrderedLocusNames=GK2394;
GN ORFNames=GKC03;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15168170; DOI=10.1007/s00792-004-0394-3;
RA Takami H., Nishi S., Lu J., Shimamura S., Takaki Y.;
RT "Genomic characterization of thermophilic Geobacillus species isolated from
RT the deepest sea mud of the Mariana Trench.";
RL Extremophiles 8:351-356(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00337}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00337};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00337}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00337}.
CC -!- SIMILARITY: Belongs to the XseB family. {ECO:0000255|HAMAP-
CC Rule:MF_00337}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18359.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD76679.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB126620; BAD18359.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000043; BAD76679.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q75TB9; -.
DR SMR; Q75TB9; -.
DR STRING; 235909.GK2394; -.
DR PRIDE; Q75TB9; -.
DR EnsemblBacteria; BAD76679; BAD76679; GK2394.
DR KEGG; gka:GK2394; -.
DR eggNOG; COG1722; Bacteria.
DR HOGENOM; CLU_145918_3_1_9; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.1040; -; 1.
DR HAMAP; MF_00337; Exonuc_7_S; 1.
DR InterPro; IPR003761; Exonuc_VII_S.
DR InterPro; IPR037004; Exonuc_VII_ssu_sf.
DR PANTHER; PTHR34137; PTHR34137; 1.
DR Pfam; PF02609; Exonuc_VII_S; 1.
DR SUPFAM; SSF116842; SSF116842; 1.
DR TIGRFAMs; TIGR01280; xseB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..79
FT /note="Exodeoxyribonuclease 7 small subunit"
FT /id="PRO_0000303708"
SQ SEQUENCE 79 AA; 9302 MW; 728F31D644ED3B81 CRC64;
MTDVKKNENM TFEEAMKKLE EIVEKLEEGN VPLEEAIAFF QEGMKLSKLC HDKLQHVEKQ
LEYMLREDGE LVPFSPEEE
