ID   AGUA_STRAW              Reviewed;         346 AA.
AC   Q82JP0;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SAV_2714;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR   EMBL; BA000030; BAC70425.1; -; Genomic_DNA.
DR   RefSeq; WP_010984146.1; NZ_JZJK01000071.1.
DR   AlphaFoldDB; Q82JP0; -.
DR   SMR; Q82JP0; -.
DR   STRING; 227882.SAV_2714; -.
DR   EnsemblBacteria; BAC70425; BAC70425; SAVERM_2714.
DR   KEGG; sma:SAVERM_2714; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_0_0_11; -.
DR   OMA; WCRDHGP; -.
DR   OrthoDB; 771174at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194342"
FT   ACT_SITE        338
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   346 AA;  37578 MW;  04B0D60BCADCD0F1 CRC64;
     MSTPAADGFR MPAEWTPHER TWMAWPGPNP TFDHPDDLAE SCRAWADVAR AIRRFEPVTV
     VCGPGRSAEA RDLLGPGIDT VERDLDDAWM RDIGPTFLTD GKGGLAAVDW TFNGWGAQSW
     ARWEHDAKIA AYVGDLAGAK TYASKLVNEG GAIHVDGEGT VLLTETVQLG AERNPGWTRE
     QVETEIHAHL GTSKAIWLPR GLTGDYPPHG FGTLGHVDIV AAFARPGVVV AHHQPDPAHP
     DHEVSKEVIG LLKAATDAHG RRIEVVEVPA PTVLEADGHW ADYSYINHYL CNGGVVLCGF
     DDPRDETAAG IFRRLFPERT VTLVDARTIF SGGGGIHCIT QQQPKN