ID   AGUA_STRCO              Reviewed;         339 AA.
AC   O86509;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SCO5527;
GN   ORFNames=SC1C2.08;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR   EMBL; AL939124; CAA19975.1; -; Genomic_DNA.
DR   PIR; T29057; T29057.
DR   RefSeq; NP_629661.1; NC_003888.3.
DR   RefSeq; WP_003973469.1; NZ_VNID01000011.1.
DR   AlphaFoldDB; O86509; -.
DR   SMR; O86509; -.
DR   STRING; 100226.SCO5527; -.
DR   GeneID; 1100967; -.
DR   KEGG; sco:SCO5527; -.
DR   PATRIC; fig|100226.15.peg.5614; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_0_0_11; -.
DR   InParanoid; O86509; -.
DR   OMA; WCRDHGP; -.
DR   PhylomeDB; O86509; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..339
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194343"
FT   ACT_SITE        331
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   339 AA;  37142 MW;  0733B636C45FB63C CRC64;
     MTFRMPPEWA PHERTWMAWP GPNATFTDAE ELAGARAAWA SVARAVRRFE PVTMVHGPGQ
     AATARELLGP DVDLVERELD DAWMRDIGPT FVTDGRGGLA AVDWVFNGWG AQDWARWEHD
     AEIARHVADL AAAPVLSSPL VNEGGAIHVD GEGTVLLTDT VQLGSGRNPG WSREEVEAEI
     HAKLGTTTAI WLPHGLAGDY GRYGTQGHVD IVAAFARPGT VVVHSQRDPR HPDHERSQLY
     LEILRGRTDA RGRRLEVVEV PAPTVLKDEE GEWADYSYIN HYVCNGGVVL CAFGDPNDEL
     AAGIFRRLFP ERTVTLVDAR TIFAGGGGIH CITQQQPRT