ID   AGUA_STRP2              Reviewed;         361 AA.
AC   Q04L01;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SPD_0814;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR   EMBL; CP000410; ABJ54341.1; -; Genomic_DNA.
DR   RefSeq; WP_000969442.1; NC_008533.2.
DR   AlphaFoldDB; Q04L01; -.
DR   SMR; Q04L01; -.
DR   STRING; 373153.SPD_0814; -.
DR   EnsemblBacteria; ABJ54341; ABJ54341; SPD_0814.
DR   GeneID; 60232807; -.
DR   KEGG; spd:SPD_0814; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_1_0_9; -.
DR   OMA; WCRDHGP; -.
DR   OrthoDB; 771174at2; -.
DR   BioCyc; SPNE373153:G1G6V-891-MON; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
DR   TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..361
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_1000070575"
FT   ACT_SITE        354
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   361 AA;  40368 MW;  01C3EF5042777FC3 CRC64;
     MMDSPKKLGY HMPAEYEPHH GTLMIWPIRP GSWPFQGKAA KRAFTQIIET IAEGERVYLL
     VEQAYLSEAQ SYLGDKVVYL DIPTNDAWAR DTGPTILVND KGKKLAVDWA FNAWGGTYDG
     LYQDYEEDDQ VASRFAEALE RPVYDAKPFV LEGGAIHSDG QGTILVTESC LLSPGRNPNL
     TKEEIENTLL ESLGAEKVIW LPYGIYQDET NEHVDNVVAF VGPAEVVLAW TDDENDPQYA
     MSKADLELLE QETDAKGCHF TIHKLPIPAV RQVVTEEDLP GYIYEEGEEE RYAGERLAAS
     YVNFYIANKA VLVPQFEDVN DQVALDILSK CFPDRKVVGI PARDILLGGG NIHCITQQIP
     E