AGUA_STRPJ
ID AGUA_STRPJ Reviewed; 361 AA.
AC B8ZP26;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SPN23F08450;
OS Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=561276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700669 / Spain 23F-1;
RX PubMed=19114491; DOI=10.1128/jb.01343-08;
RA Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C.,
RA Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D.,
RA Mitchell T.J.;
RT "Role of conjugative elements in the evolution of the multidrug-resistant
RT pandemic clone Streptococcus pneumoniae Spain23F ST81.";
RL J. Bacteriol. 191:1480-1489(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR EMBL; FM211187; CAR68677.1; -; Genomic_DNA.
DR RefSeq; WP_000969454.1; NC_011900.1.
DR AlphaFoldDB; B8ZP26; -.
DR SMR; B8ZP26; -.
DR KEGG; sne:SPN23F08450; -.
DR HOGENOM; CLU_037682_1_0_9; -.
DR OMA; WCRDHGP; -.
DR GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR HAMAP; MF_01841; Agmatine_deimin; 1.
DR InterPro; IPR017754; Agmatine_deiminase.
DR InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR PANTHER; PTHR31377; PTHR31377; 1.
DR Pfam; PF04371; PAD_porph; 1.
DR TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE 3: Inferred from homology;
KW Hydrolase.
FT CHAIN 1..361
FT /note="Putative agmatine deiminase"
FT /id="PRO_1000188418"
FT ACT_SITE 354
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ SEQUENCE 361 AA; 40356 MW; BA0BE7684673770B CRC64;
MMDSPKKLGY HMPAEYEPHH GTLMIWPTRP GSWPFQGKAA KRAFTQIIET IAEGERVYLL
VEQAYLSEAQ SYLGDKVVYL DIPTNDAWAR DTGPTILVND KGKKLAVDWA FNAWGGTYDG
LYQDYEEDDQ VASRFAEALE RPVYDAKPFV LEGGAIHSDG QGTILVTESC LLSPGRNPNL
TKEEIENTLL ESLGAEKVIW LPYGIYQDET NEHVDNVVAF VGPAEVVLAW TDDENDPQYA
MSKADLELLE QETDAKGCHF TIHKLPIPAV RQVVTEEDLP GYIYEEGEEE RYAGERLAAS
YVNFYIANKA VLVPQFEDVN DQVALDILSK CFPDRKVVGI PARDILLGGG NIHCITQQIP
E