ID   AGUA_STRPN              Reviewed;         361 AA.
AC   Q97RA4;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SP_0921;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR   EMBL; AE005672; AAK75045.1; -; Genomic_DNA.
DR   PIR; D95106; D95106.
DR   RefSeq; WP_000969445.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97RA4; -.
DR   SMR; Q97RA4; -.
DR   STRING; 170187.SP_0921; -.
DR   EnsemblBacteria; AAK75045; AAK75045; SP_0921.
DR   KEGG; spn:SP_0921; -.
DR   eggNOG; COG2957; Bacteria.
DR   OMA; WCRDHGP; -.
DR   PhylomeDB; Q97RA4; -.
DR   BioCyc; SPNE170187:G1FZB-948-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
DR   TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..361
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194345"
FT   ACT_SITE        354
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   361 AA;  40341 MW;  BFEEAF83F0773250 CRC64;
     MMDSPKKLGY HMPAEYEPHH GTLMIWPTRP GSWPFQGKAA KRAFTQIIET IAEGERVYLL
     VEQAYLSEAQ SYLGDKVVYL DIPTNDAWAR DTGPTILVND KGKKLAVDWA FNAWGGTYDG
     LYQDYEEDDQ VASRFAEALE RPVYDAKPFV LEGGAIHSDG QGTILVTESC LLSPGRNPNL
     TKEEIENTLL ESLGAEKVIW LPYGIYQDET NEHVDNVAAF VGPAELVLAW TDDENDPQYA
     MSKADLELLE QETDAKGCHF TIHKLPIPAV RQVVTEEDLP GYIYEEGEEK RYAGERLAAS
     YVNFYIANKA VLVPQFEDVN DQVALDILSK CFPDRKVVGI PARDILLGGG NIHCITQQIP
     E