AGUA_STRZP
ID AGUA_STRZP Reviewed; 361 AA.
AC C1CK08;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841}; OrderedLocusNames=SPP_0929;
OS Streptococcus pneumoniae (strain P1031).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=488223;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1031;
RX PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA Rappuoli R., Moxon E.R., Masignani V.;
RT "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT closely related species.";
RL Genome Biol. 11:R107.1-R107.19(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC {ECO:0000255|HAMAP-Rule:MF_01841}.
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DR EMBL; CP000920; ACO20603.1; -; Genomic_DNA.
DR RefSeq; WP_000969456.1; NC_012467.1.
DR AlphaFoldDB; C1CK08; -.
DR SMR; C1CK08; -.
DR KEGG; spp:SPP_0929; -.
DR HOGENOM; CLU_037682_1_0_9; -.
DR OMA; WCRDHGP; -.
DR GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR HAMAP; MF_01841; Agmatine_deimin; 1.
DR InterPro; IPR017754; Agmatine_deiminase.
DR InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR PANTHER; PTHR31377; PTHR31377; 1.
DR Pfam; PF04371; PAD_porph; 1.
DR TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE 3: Inferred from homology;
KW Hydrolase.
FT CHAIN 1..361
FT /note="Putative agmatine deiminase"
FT /id="PRO_1000188420"
FT ACT_SITE 354
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ SEQUENCE 361 AA; 40269 MW; 969298408C407306 CRC64;
MMDSPKKLGY HMPAEYEPHH GTLMIWPTRP GSWPFQGKAA KRAFTQIIET IAEGERVYLL
VEQAYLSEAQ SYLGDKVVYL DIPTNDAWAR DTGPTILVND KGKKLAVDWA FNAWGGTYDG
LYQDYEEDDQ VASRFAEALG RPVYDAKPFV LEGGAIHSDG QGTILVTESC LLSPGRNPNL
TKEEIENTLL ESLGAEKVIW LPYGIYQDET NEHVDNVAAF VGPAELVLAW TDDENDPQYA
MSKADLELLE QETDAKGCHF TIHKLPIPAV RQVVTEEDLP GYIYEEGEEK RYAGERLAAS
YVNFYIANKA VLVPQFEDVN DQVALDILSK CFPDRKVVGI PARDILLGGG NIHCITQQIP
E