ID   EXBD_HAEIN              Reviewed;         147 AA.
AC   P43009;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Biopolymer transport protein ExbD;
GN   Name=exbD; OrderedLocusNames=HI_0252;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NTHi TN106;
RX   PubMed=7828935; DOI=10.1016/0378-1119(94)00675-i;
RA   Jarosik G.P., Hansen E.J.;
RT   "Cloning and sequencing of the Haemophilus influenzae exbB and exbD
RT   genes.";
RL   Gene 152:89-92(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in the TonB-dependent energy-dependent transport of
CC       various receptor-bound substrates. {ECO:0000250}.
CC   -!- SUBUNIT: The accessory proteins ExbB and ExbD seem to form a complex
CC       with TonB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ExbD/TolR family. {ECO:0000305}.
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DR   EMBL; U08209; AAA81949.1; -; Genomic_DNA.
DR   EMBL; L42023; AAC21918.1; -; Genomic_DNA.
DR   PIR; G64057; G64057.
DR   RefSeq; NP_438421.1; NC_000907.1.
DR   RefSeq; WP_005694050.1; NC_000907.1.
DR   AlphaFoldDB; P43009; -.
DR   SMR; P43009; -.
DR   STRING; 71421.HI_0252; -.
DR   PRIDE; P43009; -.
DR   EnsemblBacteria; AAC21918; AAC21918; HI_0252.
DR   KEGG; hin:HI_0252; -.
DR   PATRIC; fig|71421.8.peg.267; -.
DR   eggNOG; COG0848; Bacteria.
DR   HOGENOM; CLU_085305_2_0_6; -.
DR   OMA; VAIVTMK; -.
DR   PhylomeDB; P43009; -.
DR   BioCyc; HINF71421:G1GJ1-266-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003400; ExbD.
DR   InterPro; IPR014171; TonB_ExbD_2.
DR   PANTHER; PTHR30558; PTHR30558; 1.
DR   Pfam; PF02472; ExbD; 1.
DR   TIGRFAMs; TIGR02804; ExbD_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..147
FT                   /note="Biopolymer transport protein ExbD"
FT                   /id="PRO_0000129120"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..147
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          125..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         70
FT                   /note="K -> R (in strain: TN106)"
FT   VARIANT         73
FT                   /note="S -> T (in strain: TN106)"
SQ   SEQUENCE   147 AA;  16178 MW;  0219279A468C62DA CRC64;
     MKKFDEINII PFIDIMLVLL TVVLITASFI SQGKIQVNVP KASTAVAFKS DELAKLLTVT
     ADKQLYFNDK PISQEALEAE IAQWNKDQKV TLKIDAEASF QDFVTITDML SKNEIKNVAI
     VSMKDKGKSA GKNSQESTPS QSVPTTP