AGUA_YERPE
ID AGUA_YERPE Reviewed; 365 AA.
AC Q8ZHG0; Q0WIA2; Q74QH2; Q8CKL4;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841};
GN OrderedLocusNames=YPO0939, y3325, YP_3503;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC {ECO:0000255|HAMAP-Rule:MF_01841}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM86875.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS63657.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAL19605.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL590842; CAL19605.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE009952; AAM86875.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63657.1; ALT_INIT; Genomic_DNA.
DR PIR; AC0115; AC0115.
DR RefSeq; YP_002345986.1; NC_003143.1.
DR AlphaFoldDB; Q8ZHG0; -.
DR SMR; Q8ZHG0; -.
DR IntAct; Q8ZHG0; 8.
DR STRING; 214092.YPO0939; -.
DR PaxDb; Q8ZHG0; -.
DR DNASU; 1148272; -.
DR EnsemblBacteria; AAM86875; AAM86875; y3325.
DR EnsemblBacteria; AAS63657; AAS63657; YP_3503.
DR KEGG; ype:YPO0939; -.
DR KEGG; ypk:y3325; -.
DR KEGG; ypm:YP_3503; -.
DR PATRIC; fig|214092.21.peg.1217; -.
DR eggNOG; COG2957; Bacteria.
DR HOGENOM; CLU_037682_1_0_6; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR HAMAP; MF_01841; Agmatine_deimin; 1.
DR InterPro; IPR017754; Agmatine_deiminase.
DR InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR PANTHER; PTHR31377; PTHR31377; 1.
DR Pfam; PF04371; PAD_porph; 1.
DR TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..365
FT /note="Putative agmatine deiminase"
FT /id="PRO_0000194348"
FT ACT_SITE 357
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ SEQUENCE 365 AA; 40377 MW; 8A188EE380CA3798 CRC64;
MLQQQALPGT PRQDGFFMPA EWAPQDAVWM LWPYRQDNWR GKAIPAQQTF AKVAEAISRA
TPVFMGVPAE FMAQAKATMP ANVTLVEMAS DDAWMRDTGP TMVINGAAER RAVDWQFNAW
GGLNGGLYAD WQQDEKVAVQ VSDFLKNAHY SAPLILEGGS IHTDGEGTLL TTAECLLNPN
RNPHLNQAQI EQLLCDYLGV THFIWLQDGV YNDETDGHID NMCCFVRPGE VALHWTDDQQ
DPQYARSVAA FEVLSNTVDA KGRKLKIWKL PAPGPLYNTE EETFDVLTSD AVPRTAGERL
AGSYVNFLIS NQQIIFPLLD SRTDGQANDL LQQMFPGYAI VGVPAREILL GGGNIHCITQ
QIPAA