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AGUA_YERPE
ID   AGUA_YERPE              Reviewed;         365 AA.
AC   Q8ZHG0; Q0WIA2; Q74QH2; Q8CKL4;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Putative agmatine deiminase {ECO:0000255|HAMAP-Rule:MF_01841};
DE            EC=3.5.3.12 {ECO:0000255|HAMAP-Rule:MF_01841};
DE   AltName: Full=Agmatine iminohydrolase {ECO:0000255|HAMAP-Rule:MF_01841};
GN   Name=aguA {ECO:0000255|HAMAP-Rule:MF_01841};
GN   OrderedLocusNames=YPO0939, y3325, YP_3503;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = N-carbamoylputrescine + NH4(+);
CC         Xref=Rhea:RHEA:18037, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58145, ChEBI:CHEBI:58318; EC=3.5.3.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01841};
CC   -!- SIMILARITY: Belongs to the agmatine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01841}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM86875.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS63657.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAL19605.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL19605.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE009952; AAM86875.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS63657.1; ALT_INIT; Genomic_DNA.
DR   PIR; AC0115; AC0115.
DR   RefSeq; YP_002345986.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZHG0; -.
DR   SMR; Q8ZHG0; -.
DR   IntAct; Q8ZHG0; 8.
DR   STRING; 214092.YPO0939; -.
DR   PaxDb; Q8ZHG0; -.
DR   DNASU; 1148272; -.
DR   EnsemblBacteria; AAM86875; AAM86875; y3325.
DR   EnsemblBacteria; AAS63657; AAS63657; YP_3503.
DR   KEGG; ype:YPO0939; -.
DR   KEGG; ypk:y3325; -.
DR   KEGG; ypm:YP_3503; -.
DR   PATRIC; fig|214092.21.peg.1217; -.
DR   eggNOG; COG2957; Bacteria.
DR   HOGENOM; CLU_037682_1_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0047632; F:agmatine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004668; F:protein-arginine deiminase activity; IEA:InterPro.
DR   GO; GO:0009446; P:putrescine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01841; Agmatine_deimin; 1.
DR   InterPro; IPR017754; Agmatine_deiminase.
DR   InterPro; IPR007466; Peptidyl-Arg-deiminase_porph.
DR   PANTHER; PTHR31377; PTHR31377; 1.
DR   Pfam; PF04371; PAD_porph; 1.
DR   TIGRFAMs; TIGR03380; agmatine_aguA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Putative agmatine deiminase"
FT                   /id="PRO_0000194348"
FT   ACT_SITE        357
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01841"
SQ   SEQUENCE   365 AA;  40377 MW;  8A188EE380CA3798 CRC64;
     MLQQQALPGT PRQDGFFMPA EWAPQDAVWM LWPYRQDNWR GKAIPAQQTF AKVAEAISRA
     TPVFMGVPAE FMAQAKATMP ANVTLVEMAS DDAWMRDTGP TMVINGAAER RAVDWQFNAW
     GGLNGGLYAD WQQDEKVAVQ VSDFLKNAHY SAPLILEGGS IHTDGEGTLL TTAECLLNPN
     RNPHLNQAQI EQLLCDYLGV THFIWLQDGV YNDETDGHID NMCCFVRPGE VALHWTDDQQ
     DPQYARSVAA FEVLSNTVDA KGRKLKIWKL PAPGPLYNTE EETFDVLTSD AVPRTAGERL
     AGSYVNFLIS NQQIIFPLLD SRTDGQANDL LQQMFPGYAI VGVPAREILL GGGNIHCITQ
     QIPAA
 
 
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