EXC6B_MOUSE
ID EXC6B_MOUSE Reviewed; 810 AA.
AC A6H5Z3; Q3UN15;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Exocyst complex component 6B;
DE AltName: Full=Exocyst complex component Sec15B;
DE AltName: Full=SEC15-like protein 2;
GN Name=Exoc6b; Synonyms=Sec15b, Sec15l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8,
CC SEC10, SEC15, EXO70 and EXO84. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H5Z3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H5Z3-2; Sequence=VSP_040840, VSP_040841;
CC -!- SIMILARITY: Belongs to the SEC15 family. {ECO:0000305}.
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DR EMBL; AK144547; BAE25933.1; -; mRNA.
DR EMBL; CH466523; EDK99119.1; -; Genomic_DNA.
DR EMBL; BC144781; AAI44782.1; -; mRNA.
DR EMBL; BC145693; AAI45694.1; -; mRNA.
DR CCDS; CCDS51824.1; -. [A6H5Z3-1]
DR RefSeq; NP_796051.2; NM_177077.2. [A6H5Z3-1]
DR AlphaFoldDB; A6H5Z3; -.
DR SMR; A6H5Z3; -.
DR BioGRID; 217843; 1.
DR ComplexPortal; CPX-4983; Exocyst, Exoc6b variant.
DR STRING; 10090.ENSMUSP00000125312; -.
DR iPTMnet; A6H5Z3; -.
DR PhosphoSitePlus; A6H5Z3; -.
DR EPD; A6H5Z3; -.
DR MaxQB; A6H5Z3; -.
DR PaxDb; A6H5Z3; -.
DR PeptideAtlas; A6H5Z3; -.
DR PRIDE; A6H5Z3; -.
DR ProteomicsDB; 275952; -. [A6H5Z3-1]
DR ProteomicsDB; 275953; -. [A6H5Z3-2]
DR Antibodypedia; 56922; 66 antibodies from 16 providers.
DR Ensembl; ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769. [A6H5Z3-1]
DR GeneID; 75914; -.
DR KEGG; mmu:75914; -.
DR UCSC; uc009cpa.2; mouse. [A6H5Z3-1]
DR UCSC; uc009cpb.2; mouse. [A6H5Z3-2]
DR CTD; 23233; -.
DR MGI; MGI:1923164; Exoc6b.
DR VEuPathDB; HostDB:ENSMUSG00000033769; -.
DR eggNOG; KOG2176; Eukaryota.
DR GeneTree; ENSGT00390000005739; -.
DR HOGENOM; CLU_009437_0_0_1; -.
DR InParanoid; A6H5Z3; -.
DR OMA; MERACDF; -.
DR OrthoDB; 81334at2759; -.
DR PhylomeDB; A6H5Z3; -.
DR TreeFam; TF315199; -.
DR BioGRID-ORCS; 75914; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Exoc6b; mouse.
DR PRO; PR:A6H5Z3; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; A6H5Z3; protein.
DR Bgee; ENSMUSG00000033769; Expressed in ear vesicle and 185 other tissues.
DR ExpressionAtlas; A6H5Z3; baseline and differential.
DR Genevisible; A6H5Z3; MM.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0090148; P:membrane fission; IC:ComplexPortal.
DR GO; GO:0000281; P:mitotic cytokinesis; IC:ComplexPortal.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IC:ComplexPortal.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:ComplexPortal.
DR Gene3D; 1.10.357.30; -; 1.
DR Gene3D; 1.20.58.670; -; 1.
DR InterPro; IPR007225; EXOC6/Sec15.
DR InterPro; IPR042045; EXOC6/Sec15_C_dom1.
DR InterPro; IPR042044; EXOC6PINT-1/Sec15/Tip20_C_dom2.
DR InterPro; IPR046361; Sec15_C.
DR PANTHER; PTHR12702; PTHR12702; 1.
DR Pfam; PF04091; Sec15; 1.
DR PIRSF; PIRSF025007; Sec15; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Exocytosis; Reference proteome;
KW Transport.
FT CHAIN 1..810
FT /note="Exocyst complex component 6B"
FT /id="PRO_0000406778"
FT REGION 258..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..118
FT /evidence="ECO:0000255"
FT VAR_SEQ 660..678
FT /note="GKVAQTACMSACKHLATSL -> VSDSSSILPFKVGNPCLTL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_040840"
FT VAR_SEQ 679..810
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_040841"
SQ SEQUENCE 810 AA; 94130 MW; 9DC3AA54A4B36084 CRC64;
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME KLETRIRNHD
REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR KLQHEGKELV IAMEELKQCR
LQQRNISATV DKLMLCLPVL EMYSKLRDQM KTKRHYPALK TLEHLEHTYL PQVSHYRFCK
VMVDNIPKLR EEIKDVSMSD LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG
SKRKSKKDVY TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF VVEDHILHTT
QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL KNLIVLFADT LQVYGFPVNQ
LFDMLLEIRD QYSETLLKKW AGVFRNILDS DNYSPIPVTS EETYKKVVGQ FPFQDIELEK
QPFPKKFPFS EFVPKVYNQI KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS
LQNVIKRKNI GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS TFAVFTHLPG
KVAQTACMSA CKHLATSLMQ LLLEAEVRQL TLGALQQFNL DVRECEQFAR SGPVPGFQED
TLQLAFIDLR QLLDLFIQWD WSTYLADYGQ PNCKYLRVNP VTALTLLEKM KDTSRKNNMF
AQFRKNERDK QKLIDTVAKQ LRGLISSHHS
