EXD_ANOGA
ID EXD_ANOGA Reviewed; 362 AA.
AC Q7PMT1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Homeobox protein extradenticle;
GN Name=exd {ECO:0000250|UniProtKB:P40427}; ORFNames=AGAP004696;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:EAA13242.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Transcription factor which acts with the selector homeodomain
CC proteins altering the regulation of downstream target genes such as
CC wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting
CC segmental identity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40427,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000255}.
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DR EMBL; AAAB01008968; EAA13242.3; -; Genomic_DNA.
DR RefSeq; XP_318146.2; XM_318146.4.
DR AlphaFoldDB; Q7PMT1; -.
DR SMR; Q7PMT1; -.
DR STRING; 7165.AGAP004696-PA; -.
DR PaxDb; Q7PMT1; -.
DR GeneID; 1278540; -.
DR KEGG; aga:AgaP_AGAP004696; -.
DR CTD; 1278540; -.
DR VEuPathDB; VectorBase:AGAP004696; -.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_041153_1_1_1; -.
DR InParanoid; Q7PMT1; -.
DR OMA; MGSAGYD; -.
DR OrthoDB; 804740at2759; -.
DR PhylomeDB; Q7PMT1; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR005542; PBX.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..362
FT /note="Homeobox protein extradenticle"
FT /id="PRO_0000341509"
FT DOMAIN 34..225
FT /note="PBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT DNA_BIND 226..288
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 41..120
FT /note="PBC-A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 123..225
FT /note="PBC-B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 305..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40621 MW; 875AB6C63772D36E CRC64;
MEDPNRMMGG HGGLMPPNYG MPTNDGQAGV DNDPRKQDIG EILQQIMNIT DQSLDEAQAR
KHTLNCHRMK PVLFAVLCEI KEKTVLSLRN TQEEEPPDPQ LMRLDNMLIA EGVAGPEKGG
GADFLSQSDL TGGQDNAIEH SDYRAKLAQI RQIYHQELEK YEQACSEFTT HVMNLLREQS
RTRPITPKEI ERMVQIIHRK FSSIQMQLKQ STCEAVMILR SRFLDARRKR RNFSKQASEI
LNEYFYSHLS NPYPSEEAKE ELARKCGITV SQVSNWFGNK RIRYKKNIGK AQEEANLYAA
KKAAGASPYS MGGPPSGAAT PMMSPAPAQD SMGYSLGSGG YDQQQPYDGS MGYDQLHQDL
SP
