EXD_DROPS
ID EXD_DROPS Reviewed; 376 AA.
AC Q29CT2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Homeobox protein extradenticle;
GN Name=exd {ECO:0000250|UniProtKB:P40427}; ORFNames=GA21419;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL29404.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Transcription factor which acts with the selector homeodomain
CC proteins altering the regulation of downstream target genes such as
CC wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting
CC segmental identity. Delimits the eye field and prevent inappropriate
CC eye development. Required for proper localization of chordotonal organs
CC within the peripheral nervous system (By similarity).
CC {ECO:0000250|UniProtKB:P40427}.
CC -!- SUBUNIT: Interacts with Ubx and hth. {ECO:0000250|UniProtKB:P40427}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40427,
CC ECO:0000255|PROSITE-ProRule:PRU00108}. Note=Nuclear translocation
CC requires interaction with hth. {ECO:0000250|UniProtKB:P40427}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL29404.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH475411; EAL29404.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001352352.1; XM_001352316.3.
DR AlphaFoldDB; Q29CT2; -.
DR SMR; Q29CT2; -.
DR STRING; 7237.FBpp0288246; -.
DR EnsemblMetazoa; FBtr0289808; FBpp0288246; FBgn0081406.
DR KEGG; dpo:Dpse_GA21419; -.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_041153_1_1_1; -.
DR InParanoid; Q29CT2; -.
DR OMA; LAHHMTA; -.
DR PhylomeDB; Q29CT2; -.
DR ChiTaRS; exd; fly.
DR Proteomes; UP000001819; Genome assembly.
DR Bgee; FBgn0081406; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR GO; GO:0007422; P:peripheral nervous system development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR005542; PBX.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..376
FT /note="Homeobox protein extradenticle"
FT /id="PRO_0000341510"
FT DOMAIN 38..237
FT /note="PBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT DNA_BIND 238..300
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 16..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..124
FT /note="PBC-A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 127..237
FT /note="PBC-B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 318..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41801 MW; 238208F36C04FE7C CRC64;
MEDPNRMMAH TGGMMAPQGY SLSGQDDGQN TGNENEVRKQ KDIGEILQQI MSISEQSLDE
AQARKHTLNC HRMKPALFSV LCEIKEKTVL SIRNTQEEEP PDPQLMRLDN MLIAEGVAGP
EKGGGGAAAA SAAAASQGGS LSIDGADNAI EHSDYRAKLA QIRQIYHQEL EKYEQACNEF
TTHVMNLLRE QSRTRPITPK EIERMVQIIH KKFSSIQMQL KQSTCEAVMI LRSRFLDARR
KRRNFSKQAS EILNEYFYSH LSNPYPSEEA KEELARKCGI TVSQVSNWFG NKRIRYKKNI
GKAQEEANLY AAKKAAGASP YSMAGPPSGT TTPMMSPAPP QDSMGYTMGS GGYDQQQPYD
NSMGGYDPNL HQDLSP
