ID   AGUD_LACLA              Reviewed;         466 AA.
AC   Q9CEY5;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Probable agmatine/putrescine antiporter AguD {ECO:0000305};
GN   Name=aguD {ECO:0000303|PubMed:23144255};
GN   Synonyms=yrfD {ECO:0000312|EMBL:AAK05797.1};
GN   ORFNames=L138484 {ECO:0000312|EMBL:AAK05797.1};
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
RN   [2]
RP   FUNCTION.
RC   STRAIN=IL1403;
RX   PubMed=23144255; DOI=10.1128/jb.01948-12;
RA   Trip H., Mulder N.L., Lolkema J.S.;
RT   "Cloning, expression, and functional characterization of secondary amino
RT   acid transporters of Lactococcus lactis.";
RL   J. Bacteriol. 195:340-350(2013).
CC   -!- FUNCTION: Probably catalyzes agmatine/putrescine exchange.
CC       {ECO:0000269|PubMed:23144255}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family.
CC       {ECO:0000305}.
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DR   EMBL; AE005176; AAK05797.1; -; Genomic_DNA.
DR   PIR; C86837; C86837.
DR   RefSeq; NP_267855.1; NC_002662.1.
DR   RefSeq; WP_010906100.1; NC_002662.1.
DR   AlphaFoldDB; Q9CEY5; -.
DR   SMR; Q9CEY5; -.
DR   STRING; 272623.L138484; -.
DR   PaxDb; Q9CEY5; -.
DR   EnsemblBacteria; AAK05797; AAK05797; L138484.
DR   KEGG; lla:L138484; -.
DR   PATRIC; fig|272623.7.peg.1823; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_020854_1_0_9; -.
DR   OMA; AWNFSGF; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   Pfam; PF13520; AA_permease_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..466
FT                   /note="Probable agmatine/putrescine antiporter AguD"
FT                   /id="PRO_0000442545"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   466 AA;  51150 MW;  0AE33FF365C3E1C6 CRC64;
     MENGKEKFSL FSAILSVICV VFVAEAAAPV AAIGNSQFFW WIVLIVAFLL PYGLITSELG
     TTYTGEGGLY DWITKAFDHR WGARASWFYW VNFPLWMASL AVLCPDLLHT MFGFQLNTGI
     SLLIELIFIW VIVLISLYPV SDSVWILNGG AVIKVFLALA LGGLGVYSAL TKGVANHYTL
     ASLLPSFDLH SLSFISVIIF NLLGFEVICT FADSMENPKK QIPQSIIIGG IVIAAIYMFS
     AFGIGVAIPT NKLSTSSGLV DSFQVMLGTP TGWFISLIAF LFMLTLVGNM VSWSQGVNNI
     ASYAADNGDM PKFFSKRRAS NGISWGAALM NGIVATFIVV IAPLLPNQDL FWSFFSLNLV
     LFLLSYIPVF PAFYKLRKID PETPRPFKVS GSDGILKVYM ALPMIIIIIS LIFTAIPLQY
     DKASLTEQLP ITIGAIIFIV IGELIIKRKL QVQVSQPSSS HMNSYS