ID   EXL1_CAEEL              Reviewed;         238 AA.
AC   O45405;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Chloride intracellular channel exl-1;
DE   AltName: Full=Exc-4-like protein;
GN   Name=exl-1; ORFNames=F26H11.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=14684823; DOI=10.1126/science.1087667;
RA   Berry K.L., Buelow H.E., Hall D.H., Hobert O.;
RT   "A C. elegans CLIC-like protein required for intracellular tube formation
RT   and maintenance.";
RL   Science 302:2134-2137(2003).
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14684823}. Membrane
CC       {ECO:0000269|PubMed:14684823}. Lysosome membrane
CC       {ECO:0000269|PubMed:14684823}. Golgi apparatus membrane
CC       {ECO:0000269|PubMed:14684823}. Note=Can be translocated to membranes,
CC       possibly as integral membrane proteins, with chloride channel activity
CC       (By similarity). Localizes to lysosomal membranes in the intestine, and
CC       to Golgi apparatus in neurons and muscle. It also localizes to dense
CC       bodies, a transmembrane structure which links the muscle cytoskeleton
CC       to the neighboring hypodermis. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the intestine, neurons and muscles.
CC       {ECO:0000269|PubMed:14684823}.
CC   -!- DOMAIN: Members of this family may change from a globular, soluble
CC       state to a state where the N-terminal domain is inserted into the
CC       membrane and functions as chloride channel. A conformation change of
CC       the N-terminal domain is thought to expose hydrophobic surfaces that
CC       trigger membrane insertion (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chloride channel CLIC family. {ECO:0000305}.
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DR   EMBL; Z81515; CAB04193.2; -; Genomic_DNA.
DR   PIR; T21429; T21429.
DR   RefSeq; NP_497000.1; NM_064599.4.
DR   AlphaFoldDB; O45405; -.
DR   SMR; O45405; -.
DR   BioGRID; 40381; 3.
DR   IntAct; O45405; 1.
DR   STRING; 6239.F26H11.5; -.
DR   EPD; O45405; -.
DR   PaxDb; O45405; -.
DR   PeptideAtlas; O45405; -.
DR   EnsemblMetazoa; F26H11.5.1; F26H11.5.1; WBGene00001371.
DR   GeneID; 175100; -.
DR   KEGG; cel:CELE_F26H11.5; -.
DR   UCSC; F26H11.5; c. elegans.
DR   CTD; 175100; -.
DR   WormBase; F26H11.5; CE24922; WBGene00001371; exl-1.
DR   eggNOG; KOG1422; Eukaryota.
DR   GeneTree; ENSGT00940000172914; -.
DR   HOGENOM; CLU_061051_0_1_1; -.
DR   InParanoid; O45405; -.
DR   OMA; DEYLMRP; -.
DR   OrthoDB; 974249at2759; -.
DR   PhylomeDB; O45405; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   Reactome; R-CEL-5578775; Ion homeostasis.
DR   PRO; PR:O45405; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001371; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:WormBase.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:WormBase.
DR   GO; GO:0000139; C:Golgi membrane; IDA:WormBase.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:WormBase.
DR   GO; GO:0005764; C:lysosome; IDA:WormBase.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0036195; C:muscle cell projection membrane; IDA:WormBase.
DR   GO; GO:0055120; C:striated muscle dense body; IDA:WormBase.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0006821; P:chloride transport; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   2: Evidence at transcript level;
KW   Chloride; Chloride channel; Cytoplasm; Golgi apparatus; Ion channel;
KW   Ion transport; Lysosome; Membrane; Reference proteome; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..238
FT                   /note="Chloride intracellular channel exl-1"
FT                   /id="PRO_0000144222"
SQ   SEQUENCE   238 AA;  27525 MW;  7E492C8056C36370 CRC64;
     MPTFSLWLPA GSNNVHPCGD PYAHHLFMRC LYHAKHDPTM KFDVKTTNVN KTSQEFKNTG
     LRRMPGISAE ESGETQTFET EDDILDFLEY LKPERGDDEE AENATCDLFR QFARFVKDVE
     HRDTAFNTEL LRLDKYLSEQ ETKFLISDDV THIDCLVLTR LHSIRVAAKM LKNYEIPADL
     SHVLDYLKAG YATEMFRVSC PSDQEIVLHW TELKDTPRLS AKDRAKLVRE EPVFSFSV