EXL3_ARATH
ID EXL3_ARATH Reviewed; 364 AA.
AC Q94CH6; Q8GZ94; Q9LQS5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=GDSL esterase/lipase EXL3;
DE EC=3.1.1.-;
DE AltName: Full=Family II extracellular lipase 3;
DE Short=Family II lipase EXL3;
DE Flags: Precursor;
GN Name=EXL3; OrderedLocusNames=At1g75900; ORFNames=T4O12.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11431566; DOI=10.1126/science.1060972;
RA Mayfield J.A., Fiebig A., Johnstone S.E., Preuss D.;
RT "Gene families from the Arabidopsis thaliana pollen coat proteome.";
RL Science 292:2482-2485(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Flower buds. {ECO:0000269|PubMed:11431566}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79815.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g75900 has been split into 2 genes: At1g75900 and At1g75910.; Evidence={ECO:0000305};
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DR EMBL; AY028611; AAK30018.1; -; mRNA.
DR EMBL; AC007396; AAF79815.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35772.1; -; Genomic_DNA.
DR EMBL; AK117131; BAC41809.1; -; mRNA.
DR PIR; A96788; A96788.
DR RefSeq; NP_177718.1; NM_106240.5.
DR AlphaFoldDB; Q94CH6; -.
DR SMR; Q94CH6; -.
DR STRING; 3702.AT1G75900.1; -.
DR PaxDb; Q94CH6; -.
DR PRIDE; Q94CH6; -.
DR ProteomicsDB; 222233; -.
DR EnsemblPlants; AT1G75900.1; AT1G75900.1; AT1G75900.
DR GeneID; 843923; -.
DR Gramene; AT1G75900.1; AT1G75900.1; AT1G75900.
DR KEGG; ath:AT1G75900; -.
DR Araport; AT1G75900; -.
DR TAIR; locus:2204324; AT1G75900.
DR eggNOG; ENOG502QW19; Eukaryota.
DR HOGENOM; CLU_015101_0_1_1; -.
DR InParanoid; Q94CH6; -.
DR OMA; IGCLRET; -.
DR OrthoDB; 704138at2759; -.
DR PhylomeDB; Q94CH6; -.
DR BioCyc; ARA:AT1G75900-MON; -.
DR PRO; PR:Q94CH6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94CH6; baseline and differential.
DR Genevisible; Q94CH6; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR008265; Lipase_GDSL_AS.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR PROSITE; PS01098; LIPASE_GDSL_SER; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..364
FT /note="GDSL esterase/lipase EXL3"
FT /id="PRO_0000367330"
FT ACT_SITE 50
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 339
FT /evidence="ECO:0000250"
FT ACT_SITE 342
FT /evidence="ECO:0000250"
FT CONFLICT 56
FT /note="M -> I (in Ref. 4; BAC41809)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 39816 MW; 0DD00318C9624490 CRC64;
MKDNSSWSCS CSWSSWKICL LSVLFLTETI TAVKLPPKLI IPAVIAFGDS IVDTGMNNNV
KTVVKCDFLP YGINFQSGVA TGRFCDGRVP ADLLAEELGI KSIVPAYLDP NLKSKDLLTG
VSFASGGSGY DPITPKLVAV ISLEDQLSYF EEYIEKVKNI VGEARKDFIV ANSLFLLVAG
SDDIANTYYT LRARPEYDVD SYTTLMSDSA SEFVTKLYGY GVRRVAVFGA PPIGCVPSQR
TLGGGILRDC ADNYNEAAKL FNSKLSPKLD SLRKTLPGIK PIYINIYDPL FDIIQNPANY
GFEVSNKGCC GTGAIEVAVL CNKITSSVCP DVSTHVFWDS YHPTEKTYKV LVSLLINKFV
NQFV