ID   EXLYS_BPSP6             Reviewed;         978 AA.
AC   Q7Y5N4;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   29-SEP-2021, entry version 66.
DE   RecName: Full=Peptidoglycan hydrolase gp36 {ECO:0000305};
DE   AltName: Full=Gene product 36 {ECO:0000305};
DE            Short=Gp36;
GN   Name=36 {ECO:0000312|EMBL:AAP48775.1};
OS   Enterobacteria phage SP6 (Bacteriophage SP6).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Autographiviridae; Molineuxvirinae; Zindervirus.
OX   NCBI_TaxID=194966 {ECO:0000312|Proteomes:UP000000843};
OH   NCBI_TaxID=90371; Salmonella typhimurium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15028677; DOI=10.1128/jb.186.7.1933-1944.2004;
RA   Dobbins A.T., George M. Jr., Basham D.A., Ford M.E., Houtz J.M.,
RA   Pedulla M.L., Lawrence J.G., Hatfull G.F., Hendrix R.W.;
RT   "Complete genomic sequence of the virulent Salmonella bacteriophage SP6.";
RL   J. Bacteriol. 186:1933-1944(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14729334; DOI=10.1016/j.jmb.2003.11.035;
RA   Scholl D., Kieleczawa J., Kemp P., Rush J., Richardson C.C., Merril C.,
RA   Adhya S., Molineux I.J.;
RT   "Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of
RT   the T7 supergroup.";
RL   J. Mol. Biol. 335:1151-1171(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Tseng T.Y., Frick D.N., Richardson C.C.;
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=14763988; DOI=10.1046/j.1365-2958.2003.03894.x;
RA   Moak M., Molineux I.J.;
RT   "Peptidoglycan hydrolytic activities associated with bacteriophage
RT   virions.";
RL   Mol. Microbiol. 51:1169-1183(2004).
CC   -!- FUNCTION: Exolysin that catalyzes the cleavage of the host
CC       peptidoglycans during virus entry. {ECO:0000269|PubMed:14763988}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
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DR   EMBL; AY288927; AAP48775.1; -; Genomic_DNA.
DR   EMBL; AY370673; AAR90027.1; -; Genomic_DNA.
DR   RefSeq; NP_853596.1; NC_004831.2.
DR   GeneID; 1481804; -.
DR   KEGG; vg:1481804; -.
DR   Proteomes; UP000000843; Genome.
DR   Proteomes; UP000001721; Genome.
DR   GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0098932; P:disruption by virus of host cell wall peptidoglycan during virus entry; IEA:UniProtKB-KW.
DR   GO; GO:0044409; P:entry into host; IDA:UniProtKB.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0099002; P:viral genome ejection through host cell envelope, short tail mechanism; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.530.40; -; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR023347; Lysozyme_dom_sf.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   4: Predicted;
KW   Antimicrobial; Bacteriolytic enzyme;
KW   Degradation of host cell envelope components during virus entry;
KW   Degradation of host peptidoglycans during virus entry; Reference proteome;
KW   Viral genome ejection through host cell envelope;
KW   Viral penetration into host cytoplasm; Viral short tail ejection system;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..978
FT                   /note="Peptidoglycan hydrolase gp36"
FT                   /id="PRO_0000432974"
FT   REGION          9..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  107532 MW;  E3CB5337CA10A6F2 CRC64;
     MAIERQAVQG LRRVQSTGGP SAASFATRQV GVQETSASGS RFLEDLVNAA GSLATVTTSI
     LNQRVEDDKV RQYNRALTGL MPTEDATVGG ARAHMLVSLQ NDIIAQTMQL SDDAQRFDGD
     DSQWEDHVIN ARMAVQDRLW DTYPELRGDK ESMRVVTNAF MEQQPKIFAA RETAKLKQEA
     EARIKSMESR ILLATRDVPG EAMGDALNQL QKEAMAMQIT KQEFDALVSQ LAANRAAIGD
     DSMIQGTKSL KDENGVSLYD RVGQLQTGEI QANRTWAAQN QVALFEKKDA AIKAFEAGQL
     NREQLLQVMQ NHNEISGGTA WSDSEIKSLF DRQAKARATS AKLEDLVARG EHGSPLGLQD
     ISKEDRKAYA GALVDAYTKL ANDEITRTGA TGEEAEAIRG RYEQMRYAKL GQQLIEDPII
     KERYGSLMQL SSANLKDMKI EPEALQTIMR ARDSIPEDAR RAVMGDKEYA FAENYDLATR
     MGYTPGQAIE FAQNASRGDK LPGSVMKELN DEVDGVVSDV ASGSWLTRGD NMSDMGRDLM
     LEEANQIARS MKVAGHNNDT IKRHLKSFLQ NQYTQLSEGF FTQGVLVKGD VRTLGDTIGA
     NQKDVPTVLR QYLDNHKQAL LDASGGMEEG DLYFDVDSKR GMFTIRAGSG RVPVTPAMPL
     SEIKGQDLLK EHYEKAVKER DEAKKNFEAN QMRMWGAGGY QSPAPEKTTA KTVGSRGIAD
     FLMSPAFASG ENLPSNFEFN YKRNNMDFYN YVAKTENGAN VGFDRVAGVY TPYKDAHGQS
     VGYGHFLTEE EKKNGYITIG EDKVPFAPGQ SQLTPERAMR LLEQDMKSHV PSTKDWAVPF
     DAMHPGVQRG LMDLSYNLGK DGIKNAPKAY AAFKAGKFTD GFIEMLSTAS TEGKRSSGLL
     VRRAEAYNLA QSGGSVPKIS EVETREDGSM YVKFSGSMSE AFVSKSILGK IGKDGWMEVY
     PPKAGALASG TKVGRIKL