ID   EXO1_BPT5               Reviewed;         325 AA.
AC   P11108; Q66LT8;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable exonuclease subunit 1 {ECO:0000305};
DE            EC=3.1.11.- {ECO:0000305};
DE   AltName: Full=D12;
GN   Name=D12;
GN   ORFNames=T5.127 {ECO:0000312|EMBL:AAS77173.1},
GN   T5p125 {ECO:0000312|EMBL:AAU05264.1};
OS   Escherichia phage T5 (Enterobacteria phage T5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
OX   NCBI_TaxID=2695836;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3057441; DOI=10.1093/nar/16.21.10353;
RA   Kaliman A.V., Kryukov V.M., Bayev A.A.;
RT   "The nucleotide sequence of the region of bacteriophage T5 early genes D10-
RT   D15.";
RL   Nucleic Acids Res. 16:10353-10354(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ksenzenko V.N., Kaliman A.V., Krutilina A.I., Shlyapnikov M.G.;
RT   "Bacteriophage T5 complete genome.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND INDUCTION.
RC   STRAIN=ATCC 11303-B5 {ECO:0000312|EMBL:AAX12055.1};
RX   PubMed=15661140; DOI=10.1016/j.virol.2004.10.049;
RA   Wang J., Jiang Y., Vincent M., Sun Y., Yu H., Wang J., Bao Q., Kong H.,
RA   Hu S.;
RT   "Complete genome sequence of bacteriophage T5.";
RL   Virology 332:45-65(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=St0 deletion mutant;
RX   PubMed=24198424; DOI=10.1128/jvi.02262-13;
RA   Zivanovic Y., Confalonieri F., Ponchon L., Lurz R., Chami M., Flayhan A.,
RA   Renouard M., Huet A., Decottignies P., Davidson A.R., Breyton C.,
RA   Boulanger P.;
RT   "Insights into bacteriophage T5 structure from analysis of its
RT   morphogenesis genes and protein components.";
RL   J. Virol. 88:1162-1174(2014).
RN   [5]
RP   FUNCTION.
RX   PubMed=2547651; DOI=10.1016/0014-5793(89)80887-7;
RA   Blinov V.M., Koonin E.V., Gorbalenya A.E., Kaliman A.V., Kryukov V.M.;
RT   "Two early genes of bacteriophage T5 encode proteins containing an NTP-
RT   binding sequence motif and probably involved in DNA replication,
RT   recombination and repair.";
RL   FEBS Lett. 252:47-52(1989).
CC   -!- FUNCTION: Possible exonuclease involved in phage DNA recombination,
CC       replication, and repair. {ECO:0000305|PubMed:2547651}.
CC   -!- SUBUNIT: Could consist of two subunits: D13 and D12.
CC       {ECO:0000250|UniProtKB:P04521}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000305|PubMed:15661140}.
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DR   EMBL; AY543070; AAS77173.1; -; Genomic_DNA.
DR   EMBL; AY692264; AAU05264.1; -; Genomic_DNA.
DR   EMBL; AY587007; AAX12055.1; -; Genomic_DNA.
DR   PIR; S01932; WCBPT5.
DR   RefSeq; YP_006955.1; NC_005859.1.
DR   GeneID; 2777608; -.
DR   KEGG; vg:2777608; -.
DR   Proteomes; UP000002107; Genome.
DR   Proteomes; UP000002141; Genome.
DR   Proteomes; UP000002503; Genome.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0099015; P:degradation of host chromosome by virus; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Bacterial host gene expression shutoff by virus;
KW   Degradation of host chromosome by virus; DNA damage; DNA repair;
KW   Early protein; Exonuclease; Host gene expression shutoff by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Probable exonuclease subunit 1"
FT                   /id="PRO_0000164936"
SQ   SEQUENCE   325 AA;  37311 MW;  45002FB4734468C0 CRC64;
     MRILFSADHH IKLGQDKVPK EWQKRRFLML GERLNDIFHN HNCDLHIAGG DILDVADPSS
     EEIELLEQFM SRLDHPGKIF TGNHEMLTKT ISCLYHYAGV INKVTSGKWE VITKPYRSPE
     FDIVPYDEIH KAKWKPPVSK LCFTHVRGEI PPHVKPEIDL TKYNCYDTVI AGDLHSYTNS
     QTIGSTRLLY PGSPLTTSFH RERTKGTNGC FIIDTDTLKV EWIELGDLPQ LIRKTIGAGE
     EMEPSDYDRV VYEVTGDVVQ LKSIKDSDLL DKKINHRVTK DAKLNLVDLD MLGELELYFR
     EVEKLSQGDI DRILARAAKY VKDYN