ID   EXO2_BPR69              Reviewed;         562 AA.
AC   O64299; Q7Y579;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Exonuclease subunit 2;
DE            EC=3.1.11.-;
DE   AltName: Full=Protein Gp46;
GN   Name=46;
OS   Escherichia phage RB69 (Bacteriophage RB69).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Mosigvirus.
OX   NCBI_TaxID=12353;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Petrov V., Nolan J., Chin D., Letarov A., Krisch H.M., Karam J.D.;
RT   "Enterobacteria phage RB69 complete genome.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-562.
RX   PubMed=9555879; DOI=10.1128/jb.180.8.2005-2013.1998;
RA   Yeh L.-S., Hsu T., Karam J.D.;
RT   "Divergence of a DNA replication gene cluster in the T4-related
RT   bacteriophage RB69.";
RL   J. Bacteriol. 180:2005-2013(1998).
CC   -!- FUNCTION: Exonuclease involved in phage DNA recombination, replication,
CC       and repair.
CC   -!- SUBUNIT: Consists of two subunits: Gp47 and Gp46.
CC   -!- SIMILARITY: To phage T5 protein D13 and to yeast RAD52. {ECO:0000305}.
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DR   EMBL; AY303349; AAP75965.1; -; Genomic_DNA.
DR   EMBL; AF039565; AAC39308.1; -; Genomic_DNA.
DR   RefSeq; NP_861753.1; NC_004928.1.
DR   GeneID; 1494179; -.
DR   KEGG; vg:1494179; -.
DR   Proteomes; UP000000876; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   ATP-binding; DNA damage; DNA repair; Exonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..562
FT                   /note="Exonuclease subunit 2"
FT                   /id="PRO_0000164938"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   562 AA;  63638 MW;  4B8A0225DF5F8D1E CRC64;
     MKSFKLNRVR YQNIMSVGGN PIDIQLDKVQ KTLITGKNGG GKSTMLEAIT FGLFGKPFRD
     VKKGQIINST NKKELLVELW MEFDDKKYFI KRGQKPNIFE ISVDGVRLDE SASSRDFQEE
     FERSIGMSYA SFKQIVVLGT AGYTPFMALS TPARRKLVED LLEVGTLAEM DKINKSQVRE
     LNSQGQVLDA KKDGVIQQIK IYNENIERQK KLSGDNVARL QNMYDDLAKE ARSLKAEIEE
     ANERLLNIVL DEDPTEAFNK IGQEAFLIKS KIDSYNKVIK MYHDGGTCPT CASQLHQGDP
     IVSKITDKLH ECNHSFEQLT CHRDNLSVLV DEYRANVKTK QDLASDIRTK KQAMIATIDK
     AKKVKAAIEQ ASAEFIDHAD EIALLQKELD KIIKTKSDIV LEKYHRGIIT DMLKDSGIKG
     AIIKKYVPLF NKQINHYLKI MEADYVFSID EEFNESIKSR GREEFSYASF SQGEKARIDI
     ALLFTWRDIA EKVSGVRINT LIMDEVMDSA TDSEGIKAIS TILNSLTDAN VFIISHRDHD
     PQAYGQHLQM SKVGRFTVMT VS