ID   EXO70_ASHGO             Reviewed;         614 AA.
AC   Q754H0;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Exocyst complex protein EXO70;
GN   Name=EXO70; OrderedLocusNames=AFR100W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Also plays a role in the assembly of the exocyst (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Bud {ECO:0000250}. Bud neck {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53471.1; -; Genomic_DNA.
DR   RefSeq; NP_985647.1; NM_211001.2.
DR   AlphaFoldDB; Q754H0; -.
DR   SMR; Q754H0; -.
DR   STRING; 33169.AAS53471; -.
DR   EnsemblFungi; AAS53471; AAS53471; AGOS_AFR100W.
DR   GeneID; 4621890; -.
DR   KEGG; ago:AGOS_AFR100W; -.
DR   eggNOG; KOG2344; Eukaryota.
DR   HOGENOM; CLU_010236_4_2_1; -.
DR   InParanoid; Q754H0; -.
DR   OMA; GPIYGNT; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0001927; P:exocyst assembly; IEA:EnsemblFungi.
DR   GO; GO:0051601; P:exocyst localization; IEA:EnsemblFungi.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:EnsemblFungi.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR004140; Exo70.
DR   InterPro; IPR046364; Exo70_C.
DR   PANTHER; PTHR12542; PTHR12542; 1.
DR   Pfam; PF03081; Exo70; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..614
FT                   /note="Exocyst complex protein EXO70"
FT                   /id="PRO_0000118964"
SQ   SEQUENCE   614 AA;  70367 MW;  EFBD9764403059DC CRC64;
     MPSIDVDEAD ILILSDGLKQ VNELTREITG SLSKITSTTS KSSKLFAPII ETNTRLNVLK
     RNIESSFDSV SSIKDLASDA SKYEIILEQE ITQVGLRKFI KTLHKVDDIM DDLREKSKST
     ADFRGIVTHL EELTMIGEKN LQIYFANKLN QIQPFDPQVY MNKKQNFPYY YDEDLNDIAA
     ILDYFGDTEQ NPVTEIFMKQ QGQLVLNSLA FLEPFTKQIT SESNVPYQRG SSGFNSYTEA
     FITFVSGVSV LIDDVFVKLP DRRPAVFCKI VAPILHNYTK ILRYNIDLVK DDINNYGLFS
     FELSENINRV HQLFKGKPLQ NNEQLLECEA ELKSISESLF KDLIQYIGQK TASLAQLPTD
     NGVTEATVDV MSRLRKFSEY KSGCLATIQS MTRESWLPNE SKNVWTISMT PKNAQQLLSC
     FFSDAIDYLT ISLERKAQKI LNPNLEPEVG APHKRIPQMQ RIGFFVLTNI TLIEQIVQRS
     EINTVLEDIG AARLVKLNAR YVNYFASDWR DLASNLLDQV FVDSSGKISS KDKDQVKEKF
     RKFNEGFEQL VSNYKTCRIT DPAMKKLLKQ EIFALVAPMY ERFHNRYKDS FKNPRKHIKY
     TPNELMNILN SLGR