ID   EXO70_CANAL             Reviewed;         667 AA.
AC   Q5AH25; A0A1D8PQZ1; Q3MPD8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Exocyst complex protein EXO70;
GN   Name=EXO70; OrderedLocusNames=CAALFM_C702050CA;
GN   ORFNames=CaJ7.0236, CaO19.13865, CaO19.6512;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA   Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA   Mikami Y.;
RT   "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT   syntenic analysis against the Saccharomyces cerevisiae genome.";
RL   Genetics 170:1525-1537(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Also plays a role in the assembly of the exocyst (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Bud {ECO:0000250}. Bud neck {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR   EMBL; AP006852; BAE44722.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30568.1; -; Genomic_DNA.
DR   RefSeq; XP_721350.1; XM_716257.2.
DR   AlphaFoldDB; Q5AH25; -.
DR   SMR; Q5AH25; -.
DR   STRING; 237561.Q5AH25; -.
DR   PRIDE; Q5AH25; -.
DR   GeneID; 3636948; -.
DR   KEGG; cal:CAALFM_C702050CA; -.
DR   CGD; CAL0000174683; EXO70.
DR   VEuPathDB; FungiDB:C7_02050C_A; -.
DR   eggNOG; KOG2344; Eukaryota.
DR   HOGENOM; CLU_010236_4_1_1; -.
DR   InParanoid; Q5AH25; -.
DR   OMA; GPIYGNT; -.
DR   OrthoDB; 410847at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0000145; C:exocyst; ISO:CGD.
DR   GO; GO:0001411; C:hyphal tip; IDA:CGD.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; ISO:CGD.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR004140; Exo70.
DR   InterPro; IPR046364; Exo70_C.
DR   PANTHER; PTHR12542; PTHR12542; 1.
DR   Pfam; PF03081; Exo70; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..667
FT                   /note="Exocyst complex protein EXO70"
FT                   /id="PRO_0000118966"
FT   REGION          460..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  76105 MW;  BE84019520CBE49D CRC64;
     MSYNLDVDEA DVAVLNQNLI RSKELFESIG KSLHKISTKS QTASSTINPV LKQVNQLTTN
     KHEVENGLKL LQEVSENASK INDLENLLNN SIENSPGGIK SYLINLNQSK NLLSQIKTQS
     KFKQFKGILY NFENLIDRSE TKVQKYYQDL INGKDSRAII DKRDEIKLIF QYFSNPQTKS
     TSNSGGNEEY VTKLYVRARS KRLIEKLKPI ESSTKPAVKA NANIPYEKGT NGITKYTDVL
     SGEIEQELII LNECQLSTHL IGPIVEESIS RYNGIINKYN QVYFKTPQEI VDNVILILEV
     LNNLIDFKVK LKQIGLNRTL EQSNFINTFE QYLETNSVIF KEFIQAIDNR FQNLGKFNEI
     NTQEVIVELM SKLRRLSEFK LALLQLIKNY SIGQWLVSQP PMRFVNVFSS VIPNSQPQAN
     SDGEEDEVIQ EYLLSSFYSD VIDAIMINIE IGLKKNTSGG DSLPSSSSTS ASTNATSGTS
     SLSLNKKSTQ GFILIKNLFM LESIVNRSQY LYQSLGSLGE ERILRLKNRF LKLFLDDWSH
     ASYIIIRDMT TIATQSAQHQ QSQQQSSNTI GTGGGTVTNL SNKEKDQVKD LFKNFNESFE
     EALFNYQKYN FGDAILKKYL SNEIKKLILN TYFKLYDKYG NSDFTKNKSK YVKYDKLNFE
     KLLNERL