EXO70_CANGA
ID EXO70_CANGA Reviewed; 623 AA.
AC Q6FJW2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Exocyst complex protein EXO70;
GN Name=EXO70; OrderedLocusNames=CAGL0M03113g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC complex which tethers secretory vesicles to the sites of exocytosis.
CC Also plays a role in the assembly of the exocyst (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Bud {ECO:0000250}. Bud neck {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR EMBL; CR380959; CAG62458.1; -; Genomic_DNA.
DR RefSeq; XP_449482.1; XM_449482.1.
DR AlphaFoldDB; Q6FJW2; -.
DR SMR; Q6FJW2; -.
DR STRING; 5478.XP_449482.1; -.
DR PRIDE; Q6FJW2; -.
DR EnsemblFungi; CAG62458; CAG62458; CAGL0M03113g.
DR GeneID; 2891490; -.
DR KEGG; cgr:CAGL0M03113g; -.
DR CGD; CAL0136511; CAGL0M03113g.
DR VEuPathDB; FungiDB:CAGL0M03113g; -.
DR eggNOG; KOG2344; Eukaryota.
DR HOGENOM; CLU_010236_4_1_1; -.
DR InParanoid; Q6FJW2; -.
DR OMA; GPIYGNT; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR GO; GO:0000145; C:exocyst; IEA:EnsemblFungi.
DR GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR GO; GO:0001927; P:exocyst assembly; IEA:EnsemblFungi.
DR GO; GO:0051601; P:exocyst localization; IEA:EnsemblFungi.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:EnsemblFungi.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:EnsemblFungi.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR004140; Exo70.
DR InterPro; IPR046364; Exo70_C.
DR PANTHER; PTHR12542; PTHR12542; 1.
DR Pfam; PF03081; Exo70; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 3: Inferred from homology;
KW Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..623
FT /note="Exocyst complex protein EXO70"
FT /id="PRO_0000118967"
SQ SEQUENCE 623 AA; 71155 MW; A66E02D0846BB80E CRC64;
MNEIDVDEAD ILVLSQGLEK TSRLTHQVNK SLAKISKTSA QSSQLFGPIL ARNNVLKTLQ
RNIDSTLNSV ASVKDLANEA SKHEVLLRKG IASLGLKPFT VELHKLEDMY QDMSVGNSRH
TENAEFHGIL KHLKEMITSS EEQLELEFIQ ILKRIEPFDP QINMEKKIPF PYYSDEDISQ
MLIIFNYFYV KSEDSRMQDI FIRERGDQML KSMAFMEPFA KKVTSSKNAP YEKGSSGFIN
YTEAVLGFIA NERSLIDDVF SQFAEIKPRV LRNILDPIVA AFCKVLMSDL IFVKSNIDNA
GLFSFELTEC ISGVQKSVKG MNLKNQMQLI DADKQVKDVT RSLFKDTVDR IKSKTNQMTT
IPSDNGVTEA TVDTMSRLRK FSEYKTGCLA AMESISRDVW LSKSFREKEY TIQSAAIADN
ETAASLLSCF LSDCIDTLVA NLERRAQTIL MPNQEPDVAN PNSARNKFKQ RIGFLVLMNM
TLVEQIVEKS ELSVMLGNLG KARIEKLKKR YVNYLVADWK DLTVNLMDTV VIDSVGKKSK
DKEQIKEKFR RFNEGFEDLI SRTKQYKLSD PALKRLLKSE IVALLMPMYD RFYGRYKDSF
KNPRKHIKYT PDDITNVISQ TLR