ID   EXO70_KLULA             Reviewed;         619 AA.
AC   Q6CK11;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Exocyst complex protein EXO70;
GN   Name=EXO70; OrderedLocusNames=KLLA0F14421g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Also plays a role in the assembly of the exocyst (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Bud {ECO:0000250}. Bud neck {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98436.1; -; Genomic_DNA.
DR   RefSeq; XP_455728.1; XM_455728.1.
DR   AlphaFoldDB; Q6CK11; -.
DR   SMR; Q6CK11; -.
DR   STRING; 28985.XP_455728.1; -.
DR   EnsemblFungi; CAG98436; CAG98436; KLLA0_F14421g.
DR   GeneID; 2894983; -.
DR   KEGG; kla:KLLA0_F14421g; -.
DR   eggNOG; KOG2344; Eukaryota.
DR   HOGENOM; CLU_010236_4_1_1; -.
DR   InParanoid; Q6CK11; -.
DR   OMA; GPIYGNT; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0000145; C:exocyst; IEA:EnsemblFungi.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0001927; P:exocyst assembly; IEA:EnsemblFungi.
DR   GO; GO:0051601; P:exocyst localization; IEA:EnsemblFungi.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:EnsemblFungi.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR004140; Exo70.
DR   InterPro; IPR046364; Exo70_C.
DR   PANTHER; PTHR12542; PTHR12542; 1.
DR   Pfam; PF03081; Exo70; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..619
FT                   /note="Exocyst complex protein EXO70"
FT                   /id="PRO_0000118971"
SQ   SEQUENCE   619 AA;  71194 MW;  97EF52110DAA46CD CRC64;
     MSSIDINEAD VIVLSEGLKK LDSLYSEMSQ SLKKISSTTS TASQLFTPIL KKNQQLNILQ
     YNIESSLNSV ASVKDLANDA SKHEIILEQS IAKVGLKPYI NAIHKIDDIL EDLNERTHSN
     DTSEFAGMVT HLKELIFDGE RNLQIYFNKL LNSIQPFDPQ INMNKKIPFP YYDDEYLGQM
     SLILDYFENS TQNAQIVDLF IKQRVRLISQ SLAFLEPFTK QISSGPNVPY QKGSSGVNSY
     TEAMLGFIAN ENSLIQDLYS KETSRQPVIY AKLCSPIIQN YLKIIRHNRQ LLKDNRENIG
     LFSFELSDKV NDVLRSLRGK DIAEADYLNS ELIEIQRISH SLFQELFAYI NTKTRSMSQL
     PSDNGVPEPT VDIMSKIRKF SEYKSGCLST IQAMSRSQWL PKDPKISWTI TKNQLEDLSS
     ANLLSSFFGD AIDYLLFGLE RRAQETLNPQ HEIHLLSNKR FPNIQRIGFF LLNNLSLIDQ
     IVQRSEINSI LGSAGLARLE SLRKKYINYY VSDWRDLTSI LLDQIFVDSS GKVSSKEKDQ
     IKEKFKKFHD GFEDLVSRSK SYRISDPALK KILRQEILSL VLPMYERFYN RYKDSFKHPR
     KHIKYTPSEL MNVLNTIIK