ID   EXO70_NEUCR             Reviewed;         640 AA.
AC   Q6MFS1; Q7SAM9;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Exocyst complex protein exo70;
GN   Name=exo70; ORFNames=B2N18.170, NCU08012;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Also plays a role in the assembly of the exocyst (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Bud {ECO:0000250}. Bud neck {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE85518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX897674; CAE85518.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002239; EAA33446.3; -; Genomic_DNA.
DR   RefSeq; XP_962682.3; XM_957589.3.
DR   AlphaFoldDB; Q6MFS1; -.
DR   SMR; Q6MFS1; -.
DR   STRING; 5141.EFNCRP00000008266; -.
DR   EnsemblFungi; EAA33446; EAA33446; NCU08012.
DR   GeneID; 3878846; -.
DR   KEGG; ncr:NCU08012; -.
DR   VEuPathDB; FungiDB:NCU08012; -.
DR   HOGENOM; CLU_010236_4_2_1; -.
DR   InParanoid; Q6MFS1; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR004140; Exo70.
DR   InterPro; IPR046364; Exo70_C.
DR   PANTHER; PTHR12542; PTHR12542; 1.
DR   Pfam; PF03081; Exo70; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..640
FT                   /note="Exocyst complex protein exo70"
FT                   /id="PRO_0000118972"
SQ   SEQUENCE   640 AA;  70503 MW;  DCBD2B5A5F3FE2D3 CRC64;
     MAVGLINGRL AADEEARAEV DVLNSRLEKT SQLTKKIQAC LARLDATGKS VRDVAGPLSG
     ETRKLQVLGN NIDAVIAAIE KLRSPADSKN DEEQIIRMGP EKAGLPNYLA SIKRLNKALN
     DMKASNLRST QQTVADLQRL VKTGNSQLES SFDKLLRSET PRAIEPLHYL TKNMPFPVLS
     QEKITRLGLM NSYLTGVHQQ NTGAGSSQES PVIKIYAEVR AQYLLSTLGN LATASTNTAK
     KKTPEAVYKA GTNGMGTYAQ AMEGLFLAEY DNICSIFMRE DWGPVFQATC QPALVELGRT
     LRELNSHIKS HITTDCYLAY EIVEIISSLS SNLENRTGEL KSSLAAALKP IRETAKSSLV
     DLLEETKRQV NSLQTLPADG APTPLATQTM QRLQSMVNFL RPISSIMISI GDGGWKSAAA
     SKGGATDTIP SLVSFDVGAD GQEIFAHYCA DTIETLLSSL DARARVLYQQ KKAVIGVFLA
     NNVTVIERMI NESGLVTLLQ SRLQVLDVWR KKATALYTET CKEISIHLFD TVHTNRTARP
     GSGQGMVSSA SIMKGLSSKD KEKIKGMFTA FNSGFEDMVA RHKQFTMEKE VRQMLAQDVQ
     HMLEPLYNRF WDRYHEIDKG KGKYVKYDKG SIAAVFRSLY