EXO70_SCHPO
ID EXO70_SCHPO Reviewed; 615 AA.
AC Q10339;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Exocyst complex component exo70;
GN Name=exo70; ORFNames=SPBC106.20, SPBC582.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=11854409; DOI=10.1091/mbc.01-11-0542;
RA Wang H., Tang X., Liu J., Trautmann S., Balasundaram D., McCollum D.,
RA Balasubramanian M.K.;
RT "The multiprotein exocyst complex is essential for cell separation in
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 13:515-529(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND SER-418, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Required for exocytosis. {ECO:0000250}.
CC -!- SUBUNIT: The exocyst complex is composed of sec3, sec5, sec6, sec8,
CC sec10, sec15, exo70 and exo84.
CC -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB53736.1; -; Genomic_DNA.
DR PIR; T37981; T37981.
DR RefSeq; NP_595170.2; NM_001021078.2.
DR AlphaFoldDB; Q10339; -.
DR SMR; Q10339; -.
DR BioGRID; 276664; 29.
DR STRING; 4896.SPBC106.20.1; -.
DR iPTMnet; Q10339; -.
DR MaxQB; Q10339; -.
DR PaxDb; Q10339; -.
DR PRIDE; Q10339; -.
DR EnsemblFungi; SPBC106.20.1; SPBC106.20.1:pep; SPBC106.20.
DR GeneID; 2540127; -.
DR KEGG; spo:SPBC106.20; -.
DR PomBase; SPBC106.20; exo70.
DR VEuPathDB; FungiDB:SPBC106.20; -.
DR eggNOG; KOG2344; Eukaryota.
DR HOGENOM; CLU_010236_4_2_1; -.
DR InParanoid; Q10339; -.
DR OMA; CDQAKPL; -.
DR PhylomeDB; Q10339; -.
DR PRO; PR:Q10339; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000145; C:exocyst; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; TAS:PomBase.
DR GO; GO:0006887; P:exocytosis; IGI:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR004140; Exo70.
DR InterPro; IPR046364; Exo70_C.
DR PANTHER; PTHR12542; PTHR12542; 1.
DR Pfam; PF03081; Exo70; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 1: Evidence at protein level;
KW Exocytosis; Phosphoprotein; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..615
FT /note="Exocyst complex component exo70"
FT /id="PRO_0000118973"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 418
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 615 AA; 69042 MW; 20A137C4D815BA23 CRC64;
MSGGIFDDNK AGFETFQKNL NSVAKNVSDA SNILLSMDKR LSGLEASAGI LRDDVTNYNR
VSSNIYDTLK EMESLQVIHS HLPVLQKGLQ ECQNLNKSVS QNLKSVMDIL KSLAEDYTSL
EGSPLQFASK SQQKVEMMLS EGCQILGALC YNILETYAAS SLNKASTLLD LSIPWSFPNE
SLQQFIGLIQ QFDADVLFPV SCSSDISNIY IKIKGECVVK LLHAVSMRTD EIKLNEGSVN
FVTGKEDVSI NLVALSRLLP AVASELLLLF DQVTAKALYP KIVKPAINTV TNATRQLEGV
YEKRGAAENF VLLSLIDCIV VTRQNMNNLM PFEDASFLGF VNGVGREMEK ILISSISRLY
NGTCHNNKTV PLTTDRVSEM THGIMSFLNE LAEHENASYL LESIGNWGWR HEINADLSPA
RSVQDITRNY VMDCMDSYLT SVQTAAQAVD TIGWKMGVML LNISVYFEAK CLESKIASFL
QDVDLEKLGD RSQKYSTMYM EVWRQCSQNM LDSTYTKSQN KSTMSAKERE ITKEKFRNFN
EQVTSVVQVH RESVRFETGV ATFLLQEVKK TVLPLYQRFY DKYINSDFTK NKDKYIKFTK
ADLDSFITSA FAPSL
