ID   EXO74_BPE32             Reviewed;         185 AA.
AC   B0FIN6;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   23-FEB-2022, entry version 49.
DE   RecName: Full=3'-5' exonuclease gp74 {ECO:0000303|PubMed:18294652};
DE            EC=3.1.11.- {ECO:0000305};
GN   OrderedLocusNames=74;
OS   Escherichia phage Phieco32 (Escherichia coli phage phi32).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Podoviridae; Kuravirus.
OX   NCBI_TaxID=490103 {ECO:0000312|Proteomes:UP000002006};
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18294652; DOI=10.1016/j.jmb.2007.12.077;
RA   Savalia D., Westblade L.F., Goel M., Florens L., Kemp P., Akulenko N.,
RA   Pavlova O., Padovan J.C., Chait B.T., Washburn M.P., Ackermann H.W.,
RA   Mushegian A., Gabisonia T., Molineux I., Severinov K.;
RT   "Genomic and proteomic analysis of phiEco32, a novel Escherichia coli
RT   bacteriophage.";
RL   J. Mol. Biol. 377:774-789(2008).
CC   -!- FUNCTION: Probable 3'-5' exonuclease involved in viral DNA replication.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU330206; ABY52875.1; -; Genomic_DNA.
DR   RefSeq; YP_001671819.1; NC_010324.1.
DR   SMR; B0FIN6; -.
DR   GeneID; 5896926; -.
DR   KEGG; vg:5896926; -.
DR   Proteomes; UP000002006; Genome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   4: Predicted;
KW   DNA replication; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Viral DNA replication.
FT   CHAIN           1..185
FT                   /note="3'-5' exonuclease gp74"
FT                   /id="PRO_0000431829"
SQ   SEQUENCE   185 AA;  21731 MW;  DF8958C43215857C CRC64;
     MVKKKKKVFA FDIESNALYD DITKVWCIYI FDVETGERWG YRPHQIEDGI RKLTEADVLV
     GHNIIDFDLP ALKKMYPSLI NYHFNVFDTL CLSRYLKPDR IGDSPEYPKG DPRRGPRGHG
     LKQWGEFLGE LKGDYGEQEE AWDAFTEDMF TYCEQDVNLT VKVYLFLCEL TGFDPYDPPS
     LYWKM