ID   EXO84_ASPFU             Reviewed;         683 AA.
AC   Q4WM32;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Exocyst complex component exo84;
GN   Name=exo84; ORFNames=AFUA_6G11370;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Plays a role in both the assembly of the exocyst and the polarization
CC       of this complex to specific sites of the plasma membrane for
CC       exocytosis. Also involved in assembly of the spliceosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC       {ECO:0000250}. Note=Cell periphery. The polarization of EXO84 requires
CC       actin cables (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
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DR   EMBL; AAHF01000006; EAL88982.1; -; Genomic_DNA.
DR   RefSeq; XP_751020.1; XM_745927.1.
DR   AlphaFoldDB; Q4WM32; -.
DR   SMR; Q4WM32; -.
DR   STRING; 746128.CADAFUBP00007542; -.
DR   EnsemblFungi; EAL88982; EAL88982; AFUA_6G11370.
DR   GeneID; 3508325; -.
DR   KEGG; afm:AFUA_6G11370; -.
DR   eggNOG; KOG2215; Eukaryota.
DR   HOGENOM; CLU_012488_2_0_1; -.
DR   InParanoid; Q4WM32; -.
DR   OMA; SACVKWA; -.
DR   OrthoDB; 1357584at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21426; PTHR21426; 1.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasmic vesicle; Exocytosis; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..683
FT                   /note="Exocyst complex component exo84"
FT                   /id="PRO_0000118977"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          128..199
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        30..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  75752 MW;  40724D31BEE9B267 CRC64;
     MESRGLTLRS RTRRARPQIS APKPISGPLP PNSKSTDSGQ GNNVSQAVSR ERIPTNGATS
     DLVKRRYSTR YNQAPEFDAS APPVPGLPAA ASKYGGLGPP EASKKPSSDS SGPPQVDLNA
     LRDPSLPVDR SNLLANATEE EIEEYQNNLR KVRNRTSTDL QQNVYQNRTQ FIKISKEAEK
     LKGEMRTLRT LMAELTTALG QTAIGNAPNP MSPTADDWVP KRNANRSSVA NLESMWNVQL
     QTLWKTVEGS QKFLPVAPGR HIVMETGQWV ELDSATWKPR RPVHIVLLND HLLVAAKKRK
     RVDASNHRGP VPTKLVAEEC WPLQDVDMID LGANMGTGAA REEAEERGIA NAINVRVGSK
     TFTYRHDKRD SSDKGELLAT FRKAVEDLRR TLRSESDTAI KPTDGFGYAG VKHSVSQKLD
     LNASDASRDK PEVRIDVDGK QQNLRWVDGQ VDELDIDIAL QRFEEAVSGI ERLRKLARGL
     KGNSYAQQII NSKVDERAAR LASVLSRALA DTHSFLNATK TNVTWLTRLG FEDQAREAYL
     KARSDVISKR VRACVFEGDL PLYIFQVSYV YFTLIKNTIN IYQQCFPAVL TSACIKWAKH
     HLDGFNALLT RQLSSVQRGT TVWQKCIDIV HEHADSLTEV GVDFVDLVAK GLDLHDNGGE
     KPQMTRSESL ISGLADAARD HAF