ID   EXO84_CRYNB             Reviewed;         675 AA.
AC   P0CN63; Q55N86; Q55N87; Q5KBL6; Q5KBL7; Q5KBL8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Exocyst complex component EXO84;
GN   Name=EXO84; OrderedLocusNames=CNBH1990;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Plays a role in both the assembly of the exocyst and the polarization
CC       of this complex to specific sites of the plasma membrane for
CC       exocytosis. Also involved in assembly of the spliceosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC       {ECO:0000250}. Note=Cell periphery. The polarization of EXO84 requires
CC       actin cables (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL19098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAEY01000042; EAL19099.1; -; Genomic_DNA.
DR   EMBL; AAEY01000042; EAL19098.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_773745.1; XM_768652.1.
DR   RefSeq; XP_773746.1; XM_768653.1.
DR   AlphaFoldDB; P0CN63; -.
DR   SMR; P0CN63; -.
DR   EnsemblFungi; AAW45670; AAW45670; CNI02110.
DR   EnsemblFungi; EAL19098; EAL19098; CNBH1990.
DR   EnsemblFungi; EAL19099; EAL19099; CNBH1990.
DR   GeneID; 4937721; -.
DR   KEGG; cnb:CNBH1990; -.
DR   HOGENOM; CLU_012488_1_1_1; -.
DR   Proteomes; UP000001435; Chromosome 8.
DR   GO; GO:0000145; C:exocyst; IEA:InterPro.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21426; PTHR21426; 2.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasmic vesicle; Exocytosis; Protein transport; Transport.
FT   CHAIN           1..675
FT                   /note="Exocyst complex component EXO84"
FT                   /id="PRO_0000410086"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          134..221
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        399..420
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..438
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   675 AA;  76106 MW;  66C8B7642F57A248 CRC64;
     MASLRRPSTA IPRGPASVQF DRGARPPLPN DNKQKRMSKV GEKIKKRLSM RYGGNESFSV
     PPPLPGASDF LTADPYGGLD IETPGEDLAA SPFGLYGASD LKESSIQSSQ PLDTQEHLVD
     ESIGRRGAAD ATLEEEWNLE ELSNEKVDAQ AYVKKVLTGA DEEEKRRFVA ALMREKQANK
     KELQRTVFKH YAEFVAISKE ISTLENDMLE LKELLGQWKD LPQLMGMEDT LAPTLDRNGN
     LERRRTQRKS VFDLQNLYRN QLTQLWSIVE GSQKYLPVVA GRHLVFELHG VVELNPATYK
     PKQNVSIFLL NDVLLIAGKR RNKGGSTTSV GDEKDRDRGR MVAERCWNLI ELGIVDVKDG
     GELVNVIKVH RGKEHCVYRT QKSDDKRALI NAFRQISREA NEKKRKDSEK EQERRKTMWL
     GDKNGNGTGN SGHPLSTIGP SMADSKDLRW IDEYGDELTM AIAIRDWEES VKLVEKGQAL
     SKSIESNSSA HSLLVSRLEQ LVPSLVSQIS HDLSSSNLRK SSSARLISLL VRLDLADHAR
     DSFLESRREL MFKRVRSIKC DGDVSIYINE LAVVIFTIIR HTSDWYMNAF KENNMASGFV
     TWAKQQIETF ADLFRRQMDA PNISESTVNE CLHVTATQNR KLLRDVGLDF TFLLSSLLQP
     SSNPSDYPHS VFTSV