EXO84_CRYNJ
ID EXO84_CRYNJ Reviewed; 675 AA.
AC P0CN62; Q55N86; Q55N87; Q5KBL6; Q5KBL7; Q5KBL8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Exocyst complex component EXO84;
GN Name=EXO84; OrderedLocusNames=CNI02110;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC complex which tethers secretory vesicles to the sites of exocytosis.
CC Plays a role in both the assembly of the exocyst and the polarization
CC of this complex to specific sites of the plasma membrane for
CC exocytosis. Also involved in assembly of the spliceosome (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000250}. Note=Cell periphery. The polarization of EXO84 requires
CC actin cables (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW45669.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAW45671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE017349; AAW45670.1; -; Genomic_DNA.
DR EMBL; AE017349; AAW45671.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE017349; AAW45669.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_572976.1; XM_572976.1.
DR RefSeq; XP_572977.1; XM_572977.1.
DR RefSeq; XP_572978.1; XM_572978.1.
DR AlphaFoldDB; P0CN62; -.
DR SMR; P0CN62; -.
DR STRING; 5207.AAW45671; -.
DR PaxDb; P0CN62; -.
DR EnsemblFungi; AAW45670; AAW45670; CNI02110.
DR GeneID; 3259505; -.
DR KEGG; cne:CNI02110; -.
DR VEuPathDB; FungiDB:CNI02110; -.
DR eggNOG; KOG2215; Eukaryota.
DR HOGENOM; CLU_012488_1_1_1; -.
DR InParanoid; P0CN62; -.
DR OrthoDB; 1357584at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1210; -; 1.
DR Gene3D; 1.20.58.1220; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR033961; Exo84.
DR InterPro; IPR032403; Exo84_C.
DR InterPro; IPR042561; Exo84_C_1.
DR InterPro; IPR042560; Exo84_C_2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21426; PTHR21426; 2.
DR Pfam; PF16528; Exo84_C; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasmic vesicle; Exocytosis; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..675
FT /note="Exocyst complex component EXO84"
FT /id="PRO_0000118980"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 134..221
FT /evidence="ECO:0000255"
FT COMPBIAS 399..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 76106 MW; 66C8B7642F57A248 CRC64;
MASLRRPSTA IPRGPASVQF DRGARPPLPN DNKQKRMSKV GEKIKKRLSM RYGGNESFSV
PPPLPGASDF LTADPYGGLD IETPGEDLAA SPFGLYGASD LKESSIQSSQ PLDTQEHLVD
ESIGRRGAAD ATLEEEWNLE ELSNEKVDAQ AYVKKVLTGA DEEEKRRFVA ALMREKQANK
KELQRTVFKH YAEFVAISKE ISTLENDMLE LKELLGQWKD LPQLMGMEDT LAPTLDRNGN
LERRRTQRKS VFDLQNLYRN QLTQLWSIVE GSQKYLPVVA GRHLVFELHG VVELNPATYK
PKQNVSIFLL NDVLLIAGKR RNKGGSTTSV GDEKDRDRGR MVAERCWNLI ELGIVDVKDG
GELVNVIKVH RGKEHCVYRT QKSDDKRALI NAFRQISREA NEKKRKDSEK EQERRKTMWL
GDKNGNGTGN SGHPLSTIGP SMADSKDLRW IDEYGDELTM AIAIRDWEES VKLVEKGQAL
SKSIESNSSA HSLLVSRLEQ LVPSLVSQIS HDLSSSNLRK SSSARLISLL VRLDLADHAR
DSFLESRREL MFKRVRSIKC DGDVSIYINE LAVVIFTIIR HTSDWYMNAF KENNMASGFV
TWAKQQIETF ADLFRRQMDA PNISESTVNE CLHVTATQNR KLLRDVGLDF TFLLSSLLQP
SSNPSDYPHS VFTSV
