ID   EXO84_NEUCR             Reviewed;         683 AA.
AC   Q7S8B6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Exocyst complex component exo84;
GN   Name=exo84; ORFNames=NCU06631;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC       complex which tethers secretory vesicles to the sites of exocytosis.
CC       Plays a role in both the assembly of the exocyst and the polarization
CC       of this complex to specific sites of the plasma membrane for
CC       exocytosis. Also involved in assembly of the spliceosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC       {ECO:0000250}. Note=Cell periphery. The polarization of exo84 requires
CC       actin cables (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
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DR   EMBL; CM002239; EAA32583.3; -; Genomic_DNA.
DR   RefSeq; XP_961819.3; XM_956726.3.
DR   AlphaFoldDB; Q7S8B6; -.
DR   SMR; Q7S8B6; -.
DR   STRING; 5141.EFNCRP00000006340; -.
DR   PRIDE; Q7S8B6; -.
DR   EnsemblFungi; EAA32583; EAA32583; NCU06631.
DR   GeneID; 3877967; -.
DR   KEGG; ncr:NCU06631; -.
DR   VEuPathDB; FungiDB:NCU06631; -.
DR   HOGENOM; CLU_012488_2_0_1; -.
DR   InParanoid; Q7S8B6; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21426; PTHR21426; 2.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasmic vesicle; Exocytosis; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..683
FT                   /note="Exocyst complex component exo84"
FT                   /id="PRO_0000118984"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          145..213
FT                   /evidence="ECO:0000255"
FT   COILED          388..422
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        217..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  76444 MW;  A8429D71DD98B0E2 CRC64;
     MSEERSKISL RSGGKRKNRP TISAPRQISA PIPQDNGMPQ PPPEATMADE PRMTRPRPPP
     PGGKTSDLVK KRYSTRFGNM PTDFDPSSNP MPALPDLEKY MQAQVGSPPS RGGDAGGLGP
     MGREPPRVDI RTLRDPNFAP EQYVAEVLGE ATEDEIRDYE DALKQLKARA AADLQQNVYQ
     NRTQFIKISK EAEKLKGEMR TLRNLMLELK TNTTALRASS NSADSSGSLG PEFSTGLSKR
     DRRSSITDRT ALWSAQMQAL YKSVEGSQKF LPNSQGRHVV QNAGPWIELD NATYKSRRSM
     QIFLLNDHLL IASRKKRKID GPGADARGPM TKLVADRCWH LLDVEVVDMA GTGDSSNGRN
     KLADAIMVRG GGQNESFIYR TEKPEDPEKT TLILNIRKTV EELRRNLQSE RDATNKAKET
     INYFASRDPG LLQKTELLET LSDIKDMLIE VDGKQQNLRW VESQMDELDI NIALQQIEPA
     VARIEMLKNL ASGLKNNMIA QDFISFKVDE RCARLATLVV RELVNSHNDQ KKTKRNVTWL
     VRLGFEDRAR EAYLEARSEV IQKRSRQCIF QGDLHLYIWE ISFVYFMVIR NTVICFQSCF
     PPPMMSACVK WAKEEVDAFN VILARQLSSA EEGGEVWTEC VNRAKEHASM LSDVGLDFRN
     LVGRNVGTST TVPGGASAGL GLS