EXO84_SCHPO
ID EXO84_SCHPO Reviewed; 584 AA.
AC O14226;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Exocyst complex component exo84;
GN Name=exo84; ORFNames=SPAC6F12.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in the secretory pathway as part of the exocyst
CC complex which tethers secretory vesicles to the sites of exocytosis.
CC Plays a role in both the assembly of the exocyst and the polarization
CC of this complex to specific sites of the plasma membrane for
CC exocytosis. Also involved in assembly of the spliceosome (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000250}. Note=Cell periphery. The polarization of EXO84 requires
CC actin cables (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11092.2; -; Genomic_DNA.
DR PIR; T11659; T11659.
DR RefSeq; NP_593294.2; NM_001018724.3.
DR AlphaFoldDB; O14226; -.
DR SMR; O14226; -.
DR BioGRID; 278016; 1.
DR STRING; 4896.SPAC6F12.08c.1; -.
DR iPTMnet; O14226; -.
DR MaxQB; O14226; -.
DR PaxDb; O14226; -.
DR PRIDE; O14226; -.
DR EnsemblFungi; SPAC6F12.08c.1; SPAC6F12.08c.1:pep; SPAC6F12.08c.
DR PomBase; SPAC6F12.08c; exo84.
DR VEuPathDB; FungiDB:SPAC6F12.08c; -.
DR eggNOG; KOG2215; Eukaryota.
DR HOGENOM; CLU_495363_0_0_1; -.
DR InParanoid; O14226; -.
DR OMA; LRIHMGV; -.
DR PhylomeDB; O14226; -.
DR PRO; PR:O14226; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:1990819; C:actin fusion focus; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000145; C:exocyst; ISS:PomBase.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR Gene3D; 1.20.58.1210; -; 1.
DR Gene3D; 1.20.58.1220; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR033961; Exo84.
DR InterPro; IPR032403; Exo84_C.
DR InterPro; IPR042561; Exo84_C_1.
DR InterPro; IPR042560; Exo84_C_2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21426; PTHR21426; 2.
DR Pfam; PF16528; Exo84_C; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Exocytosis; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..584
FT /note="Exocyst complex component exo84"
FT /id="PRO_0000118985"
FT REGION 19..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 68593 MW; F5B6E3BB642750B6 CRC64;
MPDNPSSFED EFMKSNHLSV ASESIPNESQ RQSPTRLRVG TSKTDDIYRQ KRQTKHIISQ
NEVFLQPKFF DNQNFDAQSY LNDVLQDLSE DEFVSLYNKL LRIHMGVRKN LEKNFYKNLN
EYVFISGEVE SMTSDFKKFQ SLLKTLETDI EGLNLVDHTH DPSDESIKQT VQRLRSSIEG
LDEAFWEAPQ RQLICEQYNW MLINIDNQRP KLLVNMLLFN DRLLVTTSHM KEVDFPAKQQ
VLYNWNLTEI SISSIETYGP AGAEMLQKEK EVSLYKLSIN HNNKTTLLAV HNSEERDYMV
RQARHHQLQE LENWSRKHDE DLEFSRELEY HTKSEQADMC SYTSFQVLCK NLDTQDILQA
YAKQRNMVKE ISMQFDHLDI QISLQEFTDA IRNLALIQNK LERGNLNELF AEFFADKLHN
RKRKVTEILL HQLGFKGISL SHGKEIVRYL RSLGHEKEGQ GVFMKSRTLL IKEKCLNVQL
EKDTPNFIDA CAFIVFRCLA QTTSSYLQLF ELKKLDPAYR NWIFQQIEAL VDLIENQYKH
LAHDRSYTDA VSKIMTYNTE LKEAKIDAMP ILQRLFDVHS KDLK
