ID   EXOB_RHILT              Reviewed;         327 AA.
AC   Q59745;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=exoB;
OS   Rhizobium leguminosarum bv. trifolii.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RS800;
RX   PubMed=9236769; DOI=10.1007/s004380050481;
RA   Sanchez-Andujar B., Coronado C., Philip-Hollingsworth S., Dazzo F.B.,
RA   Palomares A.J.;
RT   "Structure and role in symbiosis of the exoB gene of Rhizobium
RT   leguminosarum bv trifolii.";
RL   Mol. Gen. Genet. 255:131-140(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- PATHWAY: Glycan metabolism; exopolysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; X96507; CAA65359.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q59745; -.
DR   SMR; Q59745; -.
DR   UniPathway; UPA00214; -.
DR   UniPathway; UPA00631; -.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Exopolysaccharide synthesis; Galactose metabolism;
KW   Isomerase; NAD.
FT   CHAIN           1..327
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000183227"
FT   ACT_SITE        143
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         119
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   327 AA;  35927 MW;  8C0869A7A195D012 CRC64;
     MAGETVLVVG GAGYIGSHTC LDLANKGYRP VVFDNFSNGH REFVRWGPAE EGDIRDRARL
     DEVLAKHKPA AILHFAALIE VGESVKDPVS FYENNVIGTL TLLSAAQAAG INAFVFSSTC
     ATYGLPQSVP LDETHRQVPI NPYGRTKYIV EQALADYDQY GSLRSVVLRY FNAAGADFEG
     RIGEWHQPET HAIPLAIDAA LGRRQGFKVF GSDYETRDGT CVRDYIHVLD LADAHVRAVE
     YLLKGGDSVA LNLGTGTGTT VKELLGAIEE VSNRPFPVEY IGRREGDSHT LVANNDKARD
     VLGWVPQYDL SEIIRSAWDW HAKSNQH