ID   EXOC2_CAEEL             Reviewed;         884 AA.
AC   Q22706;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Exocyst complex component 2;
DE   AltName: Full=Exocyst complex component Sec5;
GN   Name=sec-5; ORFNames=T23G7.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q96KP1}.
CC   -!- SUBUNIT: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2,
CC       sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and
CC       exo-84/exoc8. {ECO:0000250|UniProtKB:O54921}.
CC   -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000305}.
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DR   EMBL; Z68319; CAA92702.1; -; Genomic_DNA.
DR   PIR; T25205; T25205.
DR   RefSeq; NP_495958.1; NM_063557.4.
DR   AlphaFoldDB; Q22706; -.
DR   SMR; Q22706; -.
DR   ComplexPortal; CPX-712; Exocyst.
DR   STRING; 6239.T23G7.4; -.
DR   EPD; Q22706; -.
DR   PaxDb; Q22706; -.
DR   PeptideAtlas; Q22706; -.
DR   EnsemblMetazoa; T23G7.4.1; T23G7.4.1; WBGene00004752.
DR   GeneID; 174459; -.
DR   KEGG; cel:CELE_T23G7.4; -.
DR   UCSC; T23G7.4; c. elegans.
DR   CTD; 174459; -.
DR   WormBase; T23G7.4; CE03705; WBGene00004752; sec-5.
DR   eggNOG; KOG2347; Eukaryota.
DR   GeneTree; ENSGT00390000010872; -.
DR   HOGENOM; CLU_005811_1_0_1; -.
DR   InParanoid; Q22706; -.
DR   OMA; ITAYHCW; -.
DR   OrthoDB; 97000at2759; -.
DR   PhylomeDB; Q22706; -.
DR   Reactome; R-CEL-264876; Insulin processing.
DR   Reactome; R-CEL-5620916; VxPx cargo-targeting to cilium.
DR   PRO; PR:Q22706; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004752; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0000145; C:exocyst; ISS:WormBase.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0090522; P:vesicle tethering involved in exocytosis; IMP:ComplexPortal.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR029175; EXOC2/Sec5.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   PANTHER; PTHR13043; PTHR13043; 1.
DR   Pfam; PF15469; Sec5; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..884
FT                   /note="Exocyst complex component 2"
FT                   /id="PRO_0000118921"
FT   DOMAIN          13..98
FT                   /note="IPT/TIG"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          178..206
FT                   /evidence="ECO:0000255"
FT   COILED          846..874
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   884 AA;  100414 MW;  8E0DD55341DD0E54 CRC64;
     MEENAQARER LPPTVTGLSP TEGVPGTQIT IRGENLGNDQ SDVIMLFICG IDSLWSMKWK
     SPSKIIARVG AASRGPGEVR IATKSGGKGS SNVKFRVFIT QIGPLEESAV WVDETRTVPG
     REAIRSVPQI QDERDALGLL PSQKRMDQVL LSRDFPDCSG NLRMENFSPQ WYLLENHADA
     TIEDLRIAIK NMELSKQNEA KRSEEMHKAN LYSLINCVDT LANLHQALEK GENADHFAAL
     KNISKLIKDS KSKAENVFAD VLKRKDDADA TRNALGVIVR FKFIFFLSSK IEDSMKKGEY
     ITILNDYTRA KSLYADTDVP LFRELMTEID EKMQVFKEEM KRKLIDTPVS YEEQSKLIKY
     LKILDPESDP TWDCITSYYV WLEKSLWDMQ TQFLEKAKLE DLENQQRINS QNHLITKTNE
     LQNFVTTLVE LLLSKLPSFW KLANTYHNST ASPDAIQRLE DINQMLTNII NVSSWLILNA
     LVPKALPDMV LKQYGDQFAK WPTVPADISR SNLQLSLKTT RSLISSLLEN QFSLTHVQPL
     VELCMTARLK LLSDFVDCGV ERVALLAHRI NWKQDILDRA QQTKTILPDY YENEICECLT
     RTRDALSISG YPGEACLFSR ERFRDTIIDL FVHLITSIKI CFDRLFIRQR PQQLAQEPGQ
     KKGNNEITTK KLLIAVGDIE FIIAKTLNNV GKKMQECGVK HVDQIQEKSR AKLSAFRTKM
     INDCIAMMSS AFEPLIASAT YEYLPDDDDI SDYAKEMILC SVLQQAELEL YAPQLAIECL
     QQTVSNALDA LLLHFSRLNQ DTSPLIVTQI VIDLTGLEEA LSTYATLAIR VQINTYRAGL
     VGRFDNQRLQ QCLKNMRTTM RMALQSLEQH AENLGDDSHN TSNI