EXOC2_DICDI
ID EXOC2_DICDI Reviewed; 1095 AA.
AC Q54VX5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Exocyst complex component 2;
DE AltName: Full=Exocyst complex component Sec5;
GN Name=exoc2; Synonyms=sec5; ORFNames=DDB_G0280081;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000250|UniProtKB:Q96KP1}.
CC -!- SUBUNIT: The exocyst complex is composed of sec3/exoc1, sec5/exoc2,
CC sec6/exoc3, sec8/exoc4, sec10/exoc5, sec15/exoc6, exo70/exoc7 and
CC exo84/exoc8. {ECO:0000250|UniProtKB:O54921}.
CC -!- SUBCELLULAR LOCATION: Midbody, Midbody ring
CC {ECO:0000250|UniProtKB:Q96KP1}.
CC -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000305}.
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DR EMBL; AAFI02000035; EAL67267.1; -; Genomic_DNA.
DR RefSeq; XP_641230.1; XM_636138.1.
DR AlphaFoldDB; Q54VX5; -.
DR STRING; 44689.DDB0233961; -.
DR PaxDb; Q54VX5; -.
DR EnsemblProtists; EAL67267; EAL67267; DDB_G0280081.
DR GeneID; 8622361; -.
DR KEGG; ddi:DDB_G0280081; -.
DR dictyBase; DDB_G0280081; exoc2.
DR eggNOG; KOG2347; Eukaryota.
DR HOGENOM; CLU_284066_0_0_1; -.
DR InParanoid; Q54VX5; -.
DR OMA; IESFGDC; -.
DR Reactome; R-DDI-264876; Insulin processing.
DR PRO; PR:Q54VX5; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR029175; EXOC2/Sec5.
DR InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR13043; PTHR13043; 1.
DR Pfam; PF15469; Sec5; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1095
FT /note="Exocyst complex component 2"
FT /id="PRO_0000329042"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 125325 MW; 5211F77FE956C38C CRC64;
MSSSDDTSSD YDDYDDYELD EDDTEKEPSK WNNVRDGWQE FLEDETAFFV SQEDQSKQSG
DIQIDDSNKF YDPLGILKLP PRKAASVKKE LLSLESESFS PVTFLSEIHS QTNFTELSIG
VKKLKEESTS KAKEIKYLVK ENFEHFVKCK DTVDEVYNLI SNSKMLEDMS GSFIKIINKS
STVYDPLLSN KKKADEIRKV LTLLNKYKVI FKLPGKIQEN IKQNEYEKAV HNYKNAKTLI
TSSQKKEFQK ILLDIEKIAE DFRIQLFHAL ADPSTKLEQL KKSIKTLMEI GNGKGDFSQI
GDPCWYFLST RYNAITLLIK QCSEDNTLPN YKIIRKLSIL LLSNVPNLFK MGVYYIEGKF
EDNKEYLRYK QQQQIQLQQQ QQLIQQQQQL QQQQQQQQSG KTKDSKSVNV VVYYLDETFS
SYRMDQEKKV KDLIELCRKR FIEEEDDEFC LYKLSEKKIK SEDKSTTTTN IKLLELSHDE
SPFKLQKKWA DKNSSTKNHR FLFKRKNEEF TVNNSKAGNG TSIYDKEANI TQIDLNASYK
THKKQNSAAT SAMNEEKFKQ LIINIMELYS SKVEQLFFDQ NQEDFPEDSD DEEENLFDQI
ISTTSVNEDG NHHHGGGGGG GGGGGDTINS SDLSIHMVEN VNEVIKCQEM LQGIGMPELY
LSSINSLTES LILHFIRQIC SEMVAEVSFL YLLEDWTINE SSEDALASGN QVDGMITTRL
MGEFVNTIKV NLAKLSFLSN KPMLLPSVES ALCEAIESFG DCLHHLAFNN ESIQSTIEDS
LNQMSNDEKA ENELNGIIPK IDISSPQQQQ QQTQNQSQQG QVQQGENQQQ QTSSYMTTEF
NSSEKLLLTL SNCSTVVSKT AVQLRGFYVG LFHQPMGSYL KKVIEKLGVL ERLILERYVN
EKNLMIGEFI TRGVLFSGST WLVNSQPTKV SSFILTILTK MVFIHHEIMK TINSIDISFG
VIQRIFEFLL ISLRHNFSLV DPLFISNEGK SQFLLDILFI ENVLESYGNE KTVKLSSFIR
KDLLFLNPIQ QQQQQQPTQS ISHQHQQQSS TSRFYSTLNY GGGSGFNINA TTANLDPILK
RNIEKTSLLF SCFKI
