ID   EXOC3_BOVIN             Reviewed;         745 AA.
AC   Q0V8C2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Exocyst complex component 3;
DE   AltName: Full=Exocyst complex component Sec6;
GN   Name=EXOC3; Synonyms=SEC6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC       EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity).
CC       Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP (By
CC       similarity). Interacts with SLC6A9 (By similarity).
CC       {ECO:0000250|UniProtKB:O60645, ECO:0000250|UniProtKB:Q62825,
CC       ECO:0000250|UniProtKB:Q6KAR6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q62825}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q62825}. Cell
CC       projection, growth cone {ECO:0000250|UniProtKB:Q62825}. Cell
CC       projection, neuron projection {ECO:0000250|UniProtKB:Q62825}. Midbody
CC       {ECO:0000250|UniProtKB:O60645}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:O60645}. Note=Perinuclear in undifferentiated
CC       PC12 cells. Redistributes to growing neurites and growth cones during
CC       NGF-induced neuronal differentiation (By similarity). During mitosis,
CC       early recruitment to the midbody requires RALA, but not RALB, and
CC       EXOC2. In late stages of cytokinesis, localization to the midbody is
CC       RALB-dependent (By similarity). {ECO:0000250|UniProtKB:O60645,
CC       ECO:0000250|UniProtKB:Q62825}.
CC   -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR   EMBL; BT026297; ABG81453.1; -; mRNA.
DR   RefSeq; NP_001069068.1; NM_001075600.1.
DR   RefSeq; XP_005221718.1; XM_005221661.3.
DR   RefSeq; XP_005221719.1; XM_005221662.3.
DR   RefSeq; XP_005221720.1; XM_005221663.3.
DR   AlphaFoldDB; Q0V8C2; -.
DR   SMR; Q0V8C2; -.
DR   STRING; 9913.ENSBTAP00000011353; -.
DR   PaxDb; Q0V8C2; -.
DR   PRIDE; Q0V8C2; -.
DR   Ensembl; ENSBTAT00000011353; ENSBTAP00000011353; ENSBTAG00000008606.
DR   GeneID; 513138; -.
DR   KEGG; bta:513138; -.
DR   CTD; 11336; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008606; -.
DR   VGNC; VGNC:28645; EXOC3.
DR   eggNOG; KOG2286; Eukaryota.
DR   GeneTree; ENSGT01030000234613; -.
DR   HOGENOM; CLU_016260_1_0_1; -.
DR   InParanoid; Q0V8C2; -.
DR   OMA; MNIGPKT; -.
DR   OrthoDB; 391172at2759; -.
DR   TreeFam; TF314979; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000008606; Expressed in retina and 106 other tissues.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.357.70; -; 1.
DR   InterPro; IPR010326; EXOC3/Sec6.
DR   InterPro; IPR042532; EXOC3/Sec6_C.
DR   PANTHER; PTHR21292; PTHR21292; 1.
DR   Pfam; PF06046; Sec6; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell projection; Cytoplasm; Exocytosis; Golgi apparatus;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..745
FT                   /note="Exocyst complex component 3"
FT                   /id="PRO_0000327375"
FT   MOD_RES         28
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O60645"
SQ   SEQUENCE   745 AA;  85581 MW;  2A0D2E8D27137215 CRC64;
     MKETDREAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA IQSQLDGVRT
     GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK DAVVRHSQLA AAVENLKNIF
     SVPEIVRETQ DLIEHGELLQ AHRKLMDLEC SRDGLMYEQY RMDSGNTRDM TLIHSYFGST
     QGLSDELAKQ LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR
     PKNWKEKMFT ILDRTVTTRI EGTQADTRES DRMWLVRHLE IIRKYVLDDL IVAKNLLAQC
     FPPHYEIFRS LLRTYHQALS ARMQDLAAED LEANEIVSLL TWVLNTYTSV EMMGNAELAP
     EVDVALLEPL LSADVVSALL DTYMSTLTSN IIAWLRKALE TDKKDWMKET EPEADQDGYY
     QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV LVLCLQQMNS FLSRYKEEAQ LYRDEHLRDR
     QHPHCYVQYM VAVVNNCQTF KESIVSLKRK YLKHEAEEGV SLSQPSMDGV LDAIAKEGCG
     SLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY RKRMIAEAHR
     RAVQEYLRAV MQKRISFRSA EERKDGAERM VREAEQLRFL FRKLASGFGE EMDSYCDTIV
     AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLAMR GDASRDMKQT IIETLEQGPA
     QASPDYVPIF KDIVVPSLNV AKLLK