EXOC3_DICDI
ID EXOC3_DICDI Reviewed; 783 AA.
AC Q54BP6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Exocyst complex component 3;
DE AltName: Full=Exocyst complex component Sec6;
GN Name=exoc3; Synonyms=sec6; ORFNames=DDB_G0293520;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: The exocyst complex is composed of sec3/exoc1, sec5/exoc2,
CC sec6/exoc3, sec8/exoc4, sec10/exoc5, sec15/exoc6, exo70/exoc7 and
CC exo84/exoc8. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q62825}.
CC Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q62825}. Cell
CC projection, growth cone {ECO:0000250|UniProtKB:Q62825}. Cell
CC projection, neuron projection {ECO:0000250|UniProtKB:Q62825}. Midbody
CC {ECO:0000250|UniProtKB:O60645}. Golgi apparatus
CC {ECO:0000250|UniProtKB:O60645}.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AAFI02000217; EAL60695.1; -; Genomic_DNA.
DR RefSeq; XP_629106.1; XM_629104.1.
DR AlphaFoldDB; Q54BP6; -.
DR SMR; Q54BP6; -.
DR STRING; 44689.DDB0233928; -.
DR PaxDb; Q54BP6; -.
DR EnsemblProtists; EAL60695; EAL60695; DDB_G0293520.
DR GeneID; 8629265; -.
DR KEGG; ddi:DDB_G0293520; -.
DR dictyBase; DDB_G0293520; exoc3.
DR eggNOG; KOG2286; Eukaryota.
DR HOGENOM; CLU_011776_1_0_1; -.
DR InParanoid; Q54BP6; -.
DR OMA; MNIGPKT; -.
DR PhylomeDB; Q54BP6; -.
DR Reactome; R-DDI-264876; Insulin processing.
DR PRO; PR:Q54BP6; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000145; C:exocyst; IDA:dictyBase.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 3: Inferred from homology;
KW Cell projection; Coiled coil; Cytoplasm; Exocytosis; Golgi apparatus;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..783
FT /note="Exocyst complex component 3"
FT /id="PRO_0000327376"
FT REGION 228..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..184
FT /evidence="ECO:0000255"
FT COILED 259..281
FT /evidence="ECO:0000255"
FT COMPBIAS 261..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 90540 MW; 159D30FACBAA5694 CRC64;
METVSLVPLE GLDDLSAQSA AIKKIEQNFS NIDSLASVTN HKISLIQQKK TIEAQIKNEV
HSELEKSKKG LETLYKSYNR INRMDESFSD TVELCSETSN LIGHYQLIKK VNTVRVNLIN
ILKEVDRLLT IPEKAAEIEQ LLSDDLNLLE IHSKLRELER LHQKALKQFE SNFEELEAIK
EMFSSVPELS HRFENKIWNI VSNSIDIAQI KPAVLVKVAQ IIEREKLHEQ KQKEKKSQNS
LISSEGIHDD DDDDDDTEVN LNNSNKQQNN ENENSSSNNN NNYDINNEDE GYDRNRSNYG
DRFLEVLIQS ISGKFEPMFL NSHNDLVQTL KDVNKMVDEL FIVMDIVQEC YPPSYDLFNF
YVDQYHTKFY SLFGSFSNLM ESSHVNNNYQ VVVTKNIPSA HILMLVEWVV KNYSRDLSRL
GIQDISPPLL DSLDPLIKIY KMHIKQLMRE WCDNIINNDN QNKPEVVDGQ YCSLAPIQLF
ESVASQLDIA AATKCQKLVV GVMEEVVSAL MYFQVQSITL LQERNHEIKL ENVIAYVNNN
SKCYDHTQTI VDKVSNILDS EHMGYLDFDP VLEGFLNVSK VATQAISSVI FRDLDECIHK
FYTVEWYQED LMQPIINTFE DYVTNDIQKY ILENYLKRLA LLLLDTLIEQ LLAQLIGGKN
KFNENTYKIL SNDCDKLLDF FKKYLRLSVV TAKVQILEDF KQMITSSIDM VPVYFRSVIN
FHKDINERVV ELVLYQRTDI SKSEITEVLG QIKTIVETVH TDPTNPPTGI FSRMNIYQRG
WFS
