EXOC3_DROME
ID EXOC3_DROME Reviewed; 738 AA.
AC Q9V8K2; Q95TT4;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Exocyst complex component 3;
DE AltName: Full=Exocyst complex component Sec6;
GN Name=Sec6 {ECO:0000312|FlyBase:FBgn0266671};
GN ORFNames=CG5341 {ECO:0000312|FlyBase:FBgn0266671};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC -!- SUBUNIT: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2,
CC Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and
CC Exo84/Exoc8. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57664.2; -; Genomic_DNA.
DR EMBL; AY058549; AAL13778.1; -; mRNA.
DR RefSeq; NP_611351.1; NM_137507.5.
DR AlphaFoldDB; Q9V8K2; -.
DR SMR; Q9V8K2; -.
DR BioGRID; 62816; 29.
DR DIP; DIP-18668N; -.
DR IntAct; Q9V8K2; 4.
DR STRING; 7227.FBpp0085888; -.
DR PaxDb; Q9V8K2; -.
DR PRIDE; Q9V8K2; -.
DR DNASU; 37142; -.
DR EnsemblMetazoa; FBtr0086709; FBpp0085888; FBgn0266671.
DR GeneID; 37142; -.
DR KEGG; dme:Dmel_CG5341; -.
DR CTD; 37142; -.
DR FlyBase; FBgn0266671; Sec6.
DR VEuPathDB; VectorBase:FBgn0266671; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR HOGENOM; CLU_016260_1_0_1; -.
DR InParanoid; Q9V8K2; -.
DR OMA; MNIGPKT; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q9V8K2; -.
DR Reactome; R-DME-264876; Insulin processing.
DR Reactome; R-DME-5620916; VxPx cargo-targeting to cilium.
DR SignaLink; Q9V8K2; -.
DR BioGRID-ORCS; 37142; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37142; -.
DR PRO; PR:Q9V8K2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0266671; Expressed in embryonic/larval hemocyte (Drosophila) and 32 other tissues.
DR Genevisible; Q9V8K2; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0000145; C:exocyst; IDA:FlyBase.
DR GO; GO:0016020; C:membrane; IDA:FlyBase.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0016028; C:rhabdomere; IDA:FlyBase.
DR GO; GO:0005915; C:zonula adherens; IDA:FlyBase.
DR GO; GO:0000149; F:SNARE binding; ISS:FlyBase.
DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR GO; GO:0032456; P:endocytic recycling; IMP:FlyBase.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IMP:FlyBase.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IMP:FlyBase.
DR GO; GO:0007269; P:neurotransmitter secretion; NAS:FlyBase.
DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
DR GO; GO:0007009; P:plasma membrane organization; IMP:FlyBase.
DR GO; GO:0072697; P:protein localization to cell cortex; IMP:FlyBase.
DR GO; GO:0072659; P:protein localization to plasma membrane; IMP:FlyBase.
DR GO; GO:0045313; P:rhabdomere membrane biogenesis; IMP:FlyBase.
DR GO; GO:0016081; P:synaptic vesicle docking; NAS:FlyBase.
DR GO; GO:0016080; P:synaptic vesicle targeting; NAS:FlyBase.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:FlyBase.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..738
FT /note="Exocyst complex component 3"
FT /id="PRO_0000118929"
FT COILED 28..91
FT /evidence="ECO:0000255"
SQ SEQUENCE 738 AA; 86664 MW; EA56ABF82AE7865A CRC64;
MDLQQLEEQA RQAALKDIQN MLQRPGQLEK VEQYRHRIAR KKASVEALLK TGMQGQLDGV
RVGLKQLETC MQDVREVRRR MDEVERLLRG VPEVYDALEV VREENTKHSQ YATAMENLKH
IFNVDASVQK TMALIEDDKL LNAHQCLADL ENSRDDLLYE LHKQPKQHAS DKITLKRHFE
KVDTVSQELE KKLRLILSRT LNTLRKKPTI IVTALRIIER EEKNDQFALQ QQKVTGFLPP
GRPKAWRRMI MDVLQQSVIT RIEGSKLEER ADNKMWLVRD LEILRQIILE DLRVVKSLCV
PCFPPHYDIF GEYVKFYHEG LSSYLDNIVR SGLEGNEYVS MMAWVTHTYP GVELMSHPDL
NVDVHRQIGT LLRPEHLKAL EDEYLQNMQR NFQEWMTKAA ETEKQEWFTE TVPDQDEEYY
HTSAPVIIFQ MIDQHLQVTN TIHQELTFKA LVMSIQQVEI FGQTYLKNVI ELKEHHFRNR
DQIKYFTHYI ITIVNNSQQM VELAQQMKQL YWPKSRTEHY EDFERLLATF QRIRAHAASY
LLEEAFLDME CHFNDLFTAK WLASNIAVDT ICVTLDDYFQ DYNHLRPNNF EMVINEAQKL
LAKRYIRALL SKRLSKPRAE CDAITRKIKT EAKRFKLFFE KIAPKISLSD SPLDLISTLS
ALLSSDIELL VLDLHTLLGS YPSLNEDHLV RLFYIRNDVK AAEVREKVQD AMKSKKAMVS
IAKQDCIFKE IVFSDKLW
