ID   EXOC4_CAEEL             Reviewed;         893 AA.
AC   Q9XWS2;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Exocyst complex component 4;
DE   AltName: Full=Exocyst complex component Sec8;
GN   Name=sec-8; ORFNames=Y106G6H.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=11560892; DOI=10.1093/genetics/159.1.133;
RA   Fares H., Greenwald I.;
RT   "Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte
RT   uptake defective mutants.";
RL   Genetics 159:133-145(2001).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q62824}.
CC   -!- SUBUNIT: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2,
CC       sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and
CC       exo-84/exoc8. {ECO:0000250|UniProtKB:Q62824}.
CC   -!- TISSUE SPECIFICITY: Pseudocoelom.
CC   -!- SIMILARITY: Belongs to the SEC8 family. {ECO:0000305}.
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DR   EMBL; AL032631; CAA21575.2; -; Genomic_DNA.
DR   PIR; T26430; T26430.
DR   RefSeq; NP_492732.2; NM_060331.5.
DR   AlphaFoldDB; Q9XWS2; -.
DR   SMR; Q9XWS2; -.
DR   BioGRID; 38340; 3.
DR   ComplexPortal; CPX-712; Exocyst.
DR   STRING; 6239.Y106G6H.7; -.
DR   EPD; Q9XWS2; -.
DR   PaxDb; Q9XWS2; -.
DR   PeptideAtlas; Q9XWS2; -.
DR   PRIDE; Q9XWS2; -.
DR   EnsemblMetazoa; Y106G6H.7.1; Y106G6H.7.1; WBGene00004753.
DR   GeneID; 172924; -.
DR   KEGG; cel:CELE_Y106G6H.7; -.
DR   UCSC; Y106G6H.7; c. elegans.
DR   CTD; 172924; -.
DR   WormBase; Y106G6H.7; CE32512; WBGene00004753; sec-8.
DR   eggNOG; KOG3691; Eukaryota.
DR   GeneTree; ENSGT00390000001439; -.
DR   HOGENOM; CLU_012416_0_0_1; -.
DR   InParanoid; Q9XWS2; -.
DR   OMA; SLPNWTD; -.
DR   OrthoDB; 96167at2759; -.
DR   PhylomeDB; Q9XWS2; -.
DR   Reactome; R-CEL-264876; Insulin processing.
DR   Reactome; R-CEL-5620916; VxPx cargo-targeting to cilium.
DR   PRO; PR:Q9XWS2; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004753; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000145; C:exocyst; ISS:WormBase.
DR   GO; GO:0032584; C:growth cone membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
DR   GO; GO:0090522; P:vesicle tethering involved in exocytosis; IMP:ComplexPortal.
DR   InterPro; IPR039682; Sec8/EXOC4.
DR   InterPro; IPR007191; Sec8_exocyst_N.
DR   PANTHER; PTHR14146; PTHR14146; 1.
DR   Pfam; PF04048; Sec8_exocyst; 1.
PE   2: Evidence at transcript level;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..893
FT                   /note="Exocyst complex component 4"
FT                   /id="PRO_0000118937"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  101015 MW;  10EBF7356E83F3A0 CRC64;
     MNENGATPVA AARRHRPLPA ERATSNSNET GLLINVIRSL TSSVSEDQRE VEKSRLEKGY
     KESGALIDRL VKNHQQDVEK CLVSFRDVSS KISNCRERIH NVRNALHTVK SLLELRRDDL
     KKLWHENAQQ KSVCEIMAKL EELREAPSKI ENLISKEQYQ QAADTVTESR ELINGRLSRV
     EGLSHLSAEI ERFTKILIDK INDTLVNMLV VEPFEKHLLH IVRTIPEHRI NQNAYCHSLS
     TKSRSGSGSV SSFSDVSAKS RIVSSVEALS TLFRTVEERH WDVDRLMMLG KNMIDKMIVN
     TVQVMKIGAN IDESNEGDTT HLKQLMQLLS AQFDSASQQH AEFGVLVEKQ LGRKDVVTSF
     WRSAQSAIEV VVSEHLDINP LLEKQNVLGT ASRKQLFRFE NTACATPNAN SSSHRTKAVI
     CKPSAYNIKV IFPILSRLME TTEKNINDSP CELRRFMHSF VMEVFVERVK GELASRIEGA
     LRGGEAVRVS TNKKILPSCE KVLNLCKEVQ DLIVSIDLYA DRFAALWLLV LTDYFKNMTD
     VYDRMTPKNP DPSLPNSEAL PTRRQKISAA WTADDDISRL LMSLPNWHAA SISPMTPAVE
     SELDVGERNK RESEILIGNL GTQAQNSLSE SDLITDMNDI KMFASLHESL RWFSDEIREL
     VHSLPANVKM MLDTCMVQVR LKDGQMIDNN SVPSAIEDCV RRLESIADSC LLLLHIEIRV
     HCFFHLAPLA KYRNTSSHNE VDPEVVALGK DLHQFHDNLK DVLSPAKLSY VFDGLGHLCA
     SLFIHYSQFM PRLTEAAKKR VCRNVWGVQQ RLSRITNRRE SDLDRARAFF DLLLDNTPDG
     ILAIVPEKRS QFTATELNYL LALSVRSDKT LASQPGALEK RQMVLNSILN QKK