EXOC5_CAEEL
ID EXOC5_CAEEL Reviewed; 659 AA.
AC Q18406;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Exocyst complex component 5;
DE AltName: Full=Exocyst complex component Sec10;
GN Name=sec-10; ORFNames=C33H5.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2,
CC sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and
CC exo-84/exoc8. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC10 family. {ECO:0000305}.
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DR EMBL; FO080768; CCD66571.1; -; Genomic_DNA.
DR PIR; T34142; T34142.
DR RefSeq; NP_501283.2; NM_068882.5.
DR AlphaFoldDB; Q18406; -.
DR SMR; Q18406; -.
DR BioGRID; 42680; 3.
DR ComplexPortal; CPX-712; Exocyst.
DR DIP; DIP-25121N; -.
DR STRING; 6239.C33H5.9; -.
DR EPD; Q18406; -.
DR PaxDb; Q18406; -.
DR PeptideAtlas; Q18406; -.
DR EnsemblMetazoa; C33H5.9.1; C33H5.9.1; WBGene00016376.
DR GeneID; 177562; -.
DR KEGG; cel:CELE_C33H5.9; -.
DR UCSC; C33H5.9; c. elegans.
DR CTD; 177562; -.
DR WormBase; C33H5.9; CE50274; WBGene00016376; sec-10.
DR eggNOG; KOG3745; Eukaryota.
DR GeneTree; ENSGT00390000012837; -.
DR HOGENOM; CLU_020771_1_1_1; -.
DR InParanoid; Q18406; -.
DR OrthoDB; 225235at2759; -.
DR PhylomeDB; Q18406; -.
DR Reactome; R-CEL-264876; Insulin processing.
DR Reactome; R-CEL-5620916; VxPx cargo-targeting to cilium.
DR SignaLink; Q18406; -.
DR PRO; PR:Q18406; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00016376; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000145; C:exocyst; ISS:WormBase.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IMP:ComplexPortal.
DR InterPro; IPR033960; EXOC5/Sec10.
DR InterPro; IPR009976; Sec10-like.
DR PANTHER; PTHR12100; PTHR12100; 1.
DR PANTHER; PTHR12100:SF0; PTHR12100:SF0; 1.
DR Pfam; PF07393; Sec10; 1.
PE 3: Inferred from homology;
KW Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..659
FT /note="Exocyst complex component 5"
FT /id="PRO_0000118946"
FT COILED 1..58
FT /evidence="ECO:0000255"
SQ SEQUENCE 659 AA; 75751 MW; C976EAF70E8163D2 CRC64;
MRFEEEIGSL QMLCDQFQNK INTLEKQMNE EKKDYVQKLH RLHEKNGEAI DKMKQLDHTM
QAVSTKVVHL GDQLESVDQP RSRAHDAHQL MQHFDEFLSD QPLNSMIFTD PDKLLESADL
VHKLYSISQE LNKDKFANVQ ARIGQRYKVV EDLLIEEFVR SQRDEKKMAE VAKILSEFKG
YSGCVDRYVD FLCQSIHPRG DGGEILADCL QLCRTQQPRI SAIFPSPHTV MQKLVLNIFT
GRMKETITAR LRECKDTDDQ EHYLRDLAYL YSSTLKMCKE LEKLHISPDS AFLSTLTDSI
FQRYIATYCS EELKYLNDQC SNLLQRFYES KKHVKKQIGG GLHELKRDVA ARLMNVETYG
GETFVAEDVA ISILQETKNA FGRANQLCDK EELPRHVENI VDVLLKYLYG EHLDYAVETG
LAGISLAESK TEPPAYFFSV VAKCTSVILL MIKQFEDPIF PIIKETIVEP SVAKKWQQSL
RSLESKMSLG LERQLNSIVG YVKFLFSEQK KTDFRPDSQQ IDIRVSPQCQ LASRFLANQV
AAMELGCDGE NLEALQSDLA TRLFKFMLTH IQQFTYNSTG AVLLLCDVGE LRTLVSKWRV
QNALTQWESL QALTNLLAVL PDQVNETAHS SLLENVDRQL IHDFVRLRTD FRSIKNFQI
