EXOC5_DROME
ID EXOC5_DROME Reviewed; 710 AA.
AC Q9XTM1; Q95TZ8;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Exocyst complex component 5;
DE AltName: Full=Exocyst complex component Sec10;
GN Name=Sec10 {ECO:0000312|FlyBase:FBgn0266673};
GN ORFNames=CG6159 {ECO:0000312|FlyBase:FBgn0266673};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Zhang Y.Q., Andrews H.K., Broadie K.S.;
RT "Dissecting the functions of the sec6/8 complex in synaptic transmission.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-710.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC -!- SUBUNIT: The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2,
CC Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and
CC Exo84/Exoc8. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL13643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ242993; CAB44702.1; -; Genomic_DNA.
DR EMBL; AJ242992; CAB44701.1; -; mRNA.
DR EMBL; AE014297; AAF56241.1; -; Genomic_DNA.
DR EMBL; AY058414; AAL13643.1; ALT_INIT; mRNA.
DR RefSeq; NP_651218.1; NM_142961.5.
DR AlphaFoldDB; Q9XTM1; -.
DR SMR; Q9XTM1; -.
DR BioGRID; 67796; 44.
DR DIP; DIP-18020N; -.
DR IntAct; Q9XTM1; 2.
DR STRING; 7227.FBpp0083932; -.
DR PaxDb; Q9XTM1; -.
DR PRIDE; Q9XTM1; -.
DR DNASU; 42863; -.
DR EnsemblMetazoa; FBtr0084547; FBpp0083932; FBgn0266673.
DR GeneID; 42863; -.
DR KEGG; dme:Dmel_CG6159; -.
DR UCSC; CG6159-RA; d. melanogaster.
DR CTD; 42863; -.
DR FlyBase; FBgn0266673; Sec10.
DR VEuPathDB; VectorBase:FBgn0266673; -.
DR eggNOG; KOG3745; Eukaryota.
DR HOGENOM; CLU_020771_1_0_1; -.
DR InParanoid; Q9XTM1; -.
DR OMA; PLCKHHY; -.
DR OrthoDB; 225235at2759; -.
DR PhylomeDB; Q9XTM1; -.
DR Reactome; R-DME-264876; Insulin processing.
DR Reactome; R-DME-5620916; VxPx cargo-targeting to cilium.
DR SignaLink; Q9XTM1; -.
DR BioGRID-ORCS; 42863; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42863; -.
DR PRO; PR:Q9XTM1; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0266673; Expressed in embryonic/larval hemocyte (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9XTM1; baseline and differential.
DR Genevisible; Q9XTM1; DM.
DR GO; GO:0000145; C:exocyst; IDA:FlyBase.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0008013; F:beta-catenin binding; IPI:FlyBase.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; NAS:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016081; P:synaptic vesicle docking; NAS:FlyBase.
DR GO; GO:0016080; P:synaptic vesicle targeting; NAS:FlyBase.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:FlyBase.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0046718; P:viral entry into host cell; HMP:FlyBase.
DR InterPro; IPR033960; EXOC5/Sec10.
DR InterPro; IPR009976; Sec10-like.
DR PANTHER; PTHR12100; PTHR12100; 1.
DR PANTHER; PTHR12100:SF0; PTHR12100:SF0; 1.
DR Pfam; PF07393; Sec10; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..710
FT /note="Exocyst complex component 5"
FT /id="PRO_0000118947"
FT COILED 44..96
FT /evidence="ECO:0000255"
SQ SEQUENCE 710 AA; 82031 MW; 256F78D2C15AD41A CRC64;
MLSQYMEEFE QEPFEVGEFI ERLTWRTNNE LQNSEDFHPV ALHDTFIQTI KDLKILQEKQ
QSKCERLEES LRQEKESHAK KIAKLQERHQ TAIDVFGQLD EKINSVAGKI MHLGEQLENV
NTPRSRSVEA QKLLNFMSEF LAAGPVIVND IFADAARLSE AADVIQKLYA ISQDLPPGNF
AESKRKIEKK YDEVERRLIE EFATAQKSED IERMKTLAQI LSQFKGYTQC VDAYIEQSQM
QPYSGKDIFI GIVPLCKHHY EIIQKVFANP QQVMSKFILN IYQLKLHQYA MTKLEDKKDE
EKYLRTLYEL YSRTLKLSTD LQIYMSTIDD DLLQKLTQQI FIKHLAGYAE METKCLTAKC
STELEKFYAS KKHQKTATTK GFRRNMEVLI ATRANINIAA IEDYGGETFL SEELAINMLQ
EAKASLKRCR LLSNETELPG NAIKLNDILL RFLMHEHVDY ALELGLQAVP LAEGRVFPQL
YFFDVVQKTN IIVHLLDKLC HTSVIPCVSN TPKYSDYVFK KRILMEQIET KLDQGLDRSI
SAVIGWVKVY LQYEQKKTDY KPETDVDTIS SAACLQVVQN LQPVIVQIKK CVDGENLQNV
LTEFGTRLHR VIYDHLQTMQ FNTAGAMCAI CDVNEYRKCI RELDSPLVTQ LFDILHALCN
LLLVKPQNLQ EVCTGDTLNY LDKSVVRQFI QLRTDFRIIK NTNYLKGIIE
