ID   EXOC6_CAEEL             Reviewed;         817 AA.
AC   Q18286;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 4.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Exocyst complex component 6;
DE   AltName: Full=Exocyst complex component Sec15;
GN   Name=sec-15; ORFNames=C28G1.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2,
CC       sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and
CC       exo-84/exoc8. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC15 family. {ECO:0000305}.
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DR   EMBL; FO080383; CCD63330.1; -; Genomic_DNA.
DR   RefSeq; NP_509496.3; NM_077095.6.
DR   AlphaFoldDB; Q18286; -.
DR   SMR; Q18286; -.
DR   BioGRID; 46050; 1.
DR   ComplexPortal; CPX-712; Exocyst.
DR   IntAct; Q18286; 1.
DR   MINT; Q18286; -.
DR   STRING; 6239.C28G1.3; -.
DR   iPTMnet; Q18286; -.
DR   EPD; Q18286; -.
DR   PaxDb; Q18286; -.
DR   PeptideAtlas; Q18286; -.
DR   PRIDE; Q18286; -.
DR   EnsemblMetazoa; C28G1.3.1; C28G1.3.1; WBGene00016188.
DR   GeneID; 181131; -.
DR   KEGG; cel:CELE_C28G1.3; -.
DR   UCSC; C28G1.3; c. elegans.
DR   CTD; 181131; -.
DR   WormBase; C28G1.3; CE37614; WBGene00016188; sec-15.
DR   eggNOG; KOG2176; Eukaryota.
DR   GeneTree; ENSGT00390000005739; -.
DR   HOGENOM; CLU_009437_0_0_1; -.
DR   InParanoid; Q18286; -.
DR   OMA; RDHYNEV; -.
DR   OrthoDB; 185623at2759; -.
DR   PhylomeDB; Q18286; -.
DR   Reactome; R-CEL-264876; Insulin processing.
DR   Reactome; R-CEL-5620916; VxPx cargo-targeting to cilium.
DR   PRO; PR:Q18286; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00016188; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0000145; C:exocyst; ISS:WormBase.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0090522; P:vesicle tethering involved in exocytosis; IMP:ComplexPortal.
DR   Gene3D; 1.10.357.30; -; 1.
DR   Gene3D; 1.20.58.670; -; 1.
DR   InterPro; IPR007225; EXOC6/Sec15.
DR   InterPro; IPR042045; EXOC6/Sec15_C_dom1.
DR   InterPro; IPR042044; EXOC6PINT-1/Sec15/Tip20_C_dom2.
DR   InterPro; IPR046361; Sec15_C.
DR   PANTHER; PTHR12702; PTHR12702; 1.
DR   Pfam; PF04091; Sec15; 1.
DR   PIRSF; PIRSF025007; Sec15; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..817
FT                   /note="Exocyst complex component 6"
FT                   /id="PRO_0000118955"
FT   COILED          87..149
FT                   /evidence="ECO:0000255"
FT   COILED          247..270
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   817 AA;  93879 MW;  906FAC5B2295F5B4 CRC64;
     MPNSSSTSQP ATTGSETAST SYVNYVEMSA EQEYFLYELE TTDSGSMGLV LRAIYDTGDV
     QSFARALQQR ISHYDKNIQK VCSFHYQSFV DAMQELMKLK EQCQDIKEET VAIDAEIQQI
     SQRLCQKKQE IVRYRKLMKN AKTAMDQIAV CLPVLENYAK LQEQMSNRKY YQALKTLEEL
     EHTHLALVEK YRFTQVLAKS MAPVRLEIKE KAYSEFKDFL ENIKKVAGRI GKHASKDTAE
     QHSFGVTDAE RAKKIQEEAR KNASNVEIEV SADGSIVKKN MSPKRNMKMQ VEDDEQVSAQ
     DLIDFTPVHR CCQIFNVLGA KEEFEQYYRQ QRKEQCDLVI EPTHKMNNFK HYVEYLDEIV
     GFFVVEDQIL MTQSNLSTTV DKDKLWDNAL MKIRQHLDAR FGGSPDVLMM LKMKKVILLF
     ILTMKSYGYA VAPLYELLQN FRDQYNEILV KEYCAQFERD LEKDNYTPIT VNSEEEFRTI
     IRKFPFYKRS MEQEPFPRRF PFSPFVTDAY TQAKNYLIGC LKFMDNLQLN TSAVDDTVRR
     CANVLLGRWA GVLKSFVHKR LSMIQLVQIT INLGYLEKSC ESLGAFITSK TSGEEAIGTT
     SHQVVLSEKV FRDVRSEVEQ QIDECMRSKV DEIIDLANYD WELPAAAGQA SEFISDLINF
     LQTTFTSFTN LPSGLAKHVC TQTCKHISQS MSDFLLSPET KCISTGALDQ FSLDVMQCEM
     FTTRCPVAGV DPQTLSMTFA DLRQLLDLVM SSDWTTFNAE YGKDHAKYLR VKASTAIVVL
     EKMIEFERKS TGFFGIAKGD RKKLLDTIVR QLKLLEI